Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges

Myocardial infarction (MI), triggered by blockage of a coronary artery, remains the most common cause of death worldwide. After MI, the capability of providing sufficient blood and oxygen significantly decreases in the heart. This event leads to depletion of oxygen from cardiac tissue and consequent...

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Bibliographic Details
Published in:Cardiovascular toxicology 2022-03, Vol.22 (3), p.207-224
Main Authors: Jenabi, Alireza, Mehdinavaz Aghdam, Rouhollah, Ebrahimi, S. A. Seyyed, Ahmadi Tafti, Seyed Hossein, Krishnan, Sasirekha, Suresh, K. Shoma, Ramalingam, Murugan
Format: Article
Language:English
Subjects:
Animals
Biological products
Biomaterials
Biomedical and Life Sciences
Biomedical materials
Biomedicine
Cardiac patients
Cardiology
Cell death
Cell Survival
Coronary artery
Depletion
Heart
Heart attack
Heart attacks
Hemoglobin
Humans
Hypoxemia
Medical research
Medicine, Experimental
Myocardial infarction
Myocardial Infarction - therapy
Oxygen
Oxygen depletion
Oxygen therapy
Oxygenation
Pharmacology/Toxicology
Tissues
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Summary:Myocardial infarction (MI), triggered by blockage of a coronary artery, remains the most common cause of death worldwide. After MI, the capability of providing sufficient blood and oxygen significantly decreases in the heart. This event leads to depletion of oxygen from cardiac tissue and consequently leads to massive cardiac cell death due to hypoxemia. Over the past few decades, many studies have been carried out to discover acceptable approaches to treat MI. However, very few have addressed the crucial role of efficient oxygen delivery to the injured heart. Thus, various strategies were developed to increase the delivery of oxygen to cardiac tissue and improve its function. Here, we have given an overall discussion of the oxygen delivery mechanisms and how the current technologies are employed to treat patients suffering from MI, including a comprehensive view on three major technical approaches such as oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs). Although oxygen therapy and HBOCs have shown promising results in several animal and clinical studies, they still have a few drawbacks which limit their effectiveness. More recent studies have investigated the efficacy of ORBs which may play a key role in the future of oxygenation of cardiac tissue. In addition, a summary of conducted studies under each approach and the remaining challenges of these methods are discussed.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-021-09696-5