Coagulation profiles and viscoelastic testing in multisystem inflammatory syndrome in children

Objective To characterize viscoelastic testing profiles of children with multisystem inflammatory syndrome in children (MIS‐C). Methods This single‐center retrospective review included 30 patients diagnosed with MIS‐C from March 1 to September 1, 2020. Thromboelastography (TEG) with platelet mapping...

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Bibliographic Details
Published in:Pediatric blood & cancer 2021-12, Vol.68 (12), p.e29355-n/a
Main Authors: Ankola, Ashish A., Bradford, Victoria R., Newburger, Jane W., Emani, Sirisha, Dionne, Audrey, Friedman, Kevin, Son, Mary Beth, Henderson, Lauren A., Lee, Pui Y., Hellinger, Amy, Hawkins, Beth, Ventresco, Courtney, Esteso, Paul, VanderPluym, Christina J.
Format: Article
Language:English
Subjects:
Aspirin
Bleeding
Children
COVID‐19
Erythrocyte sedimentation rate
Fibrinolysis
Heart surgery
Hematology
Inflammation
Lysis
MIS‐C
Multisystem inflammatory syndrome in children
Oncology
Patients
Pediatrics
Platelets
thromboelastography
Thrombosis
Viscoelasticity
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Summary:Objective To characterize viscoelastic testing profiles of children with multisystem inflammatory syndrome in children (MIS‐C). Methods This single‐center retrospective review included 30 patients diagnosed with MIS‐C from March 1 to September 1, 2020. Thromboelastography (TEG) with platelet mapping was performed in 19 (63%) patients and compared to age‐ and sex‐matched controls prior to cardiac surgery. Relationships between TEG parameters and inflammatory markers were assessed using correlation. Results Patients with MIS‐C had abnormal TEG results compared to controls, including decreased kinetic (K) time (1.1 vs. 1.7 minutes, p 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.29355