Cytomegalovirus‐related sepsis‐like syndrome in very premature infants in Japan

Background Very premature infants are at high risk of developing a symptomatic postnatal cytomegalovirus (CMV) disease, such as CMV‐related sepsis‐like syndrome (CMV‐SLS). To address the limited data regarding its clinical features, a nationwide survey of CMV‐SLS was conducted. Methods A questionnai...

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Bibliographic Details
Published in:Pediatrics international 2022-01, Vol.64 (1), p.e14994-n/a
Main Authors: Namba, Fumihiko, Nakagawa, Ryota, Haga, Mitsuhiro, Yoshimoto, Seiji, Tomobe, Yutaro, Okazaki, Kaoru, Nakamura, Kenji, Seki, Yoshiko, Kitamura, Souya, Shimokaze, Tomoyuki, Ikegami, Hitoshi, Nishida, Kosuke, Mori, Shigehiro, Tamai, Kei, Ozawa, Junichi, Tanaka, Kosuke, Miyahara, Naoyuki
Format: Article
Language:English
Subjects:
Age
Birth weight
Breast milk
Breastfeeding & lactation
Cytomegalovirus
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - epidemiology
cytomegalovirus‐related sepsis‐like syndrome
Differential diagnosis
Female
Gestational age
Humans
Infant
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Infants
Infectious Disease Transmission, Vertical
Japan - epidemiology
Middle Aged
Milk, Human
nationwide survey
Neonates
Pediatrics
Premature babies
Premature birth
premature infant
Sepsis
Sepsis - diagnosis
Sepsis - epidemiology
Surveys
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Summary:Background Very premature infants are at high risk of developing a symptomatic postnatal cytomegalovirus (CMV) disease, such as CMV‐related sepsis‐like syndrome (CMV‐SLS). To address the limited data regarding its clinical features, a nationwide survey of CMV‐SLS was conducted. Methods A questionnaire regarding CMV status and the clinical outcomes of CMV‐SLS was sent to centers with reported cases of CMV‐SLS. Results Twelve CMV‐SLS cases, nine confirmed and three probable cases, were reported during the 3‐year survey period. The median gestational age and birthweight were 25 weeks and 547 g, respectively. At disease onset, the median age was 49 days, and the corrected age was 31 weeks. Untreated breast milk was given in four cases (33%), whereas frozen breast milk was given in nine (75%). No specific symptoms and laboratory data regarding CMV‐SLS were found. Conclusions Very premature infants developed CMV‐SLS after 1 month of age. There are no symptoms and signs specific for the diagnosis of CMV‐SLS, so CMV‐SLS should be considered as a differential diagnosis for premature infants who have unexplained sepsis‐like symptoms during the convalescent phase.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.14994