Current strategies to determine antifungal and antimicrobial activity of natural compounds

[Display omitted] Fungal and microbial infections are increasingly common diseases affecting not only humans, but also animals. Despite the fact that there are wide ranges of antifungal drugs that can be used as therapy against different types of mycosis, the large-scale needed for new antifungal an...

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Bibliographic Details
Published in:Microbiological research 2021-11, Vol.252, p.126867-126867, Article 126867
Main Authors: Sanchez Armengol, Eva, Harmanci, Melisa, Laffleur, Flavia
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antifungal activity
Antifungal Agents - pharmacology
Antimicrobial activity
Bacteria
Bacteria - drug effects
Biological Products - pharmacology
Drug Discovery - methods
Drug Discovery - trends
Fungi
Fungi - drug effects
Laboratory assays
Methodologies
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Summary:[Display omitted] Fungal and microbial infections are increasingly common diseases affecting not only humans, but also animals. Despite the fact that there are wide ranges of antifungal drugs that can be used as therapy against different types of mycosis, the large-scale needed for new antifungal and antimicrobial agents is undeniable. The reasons for a great demand for new agents are low effectiveness due to the development of resistance, host toxicity and various side effects of currently used therapeutics. In order to develop novel drugs against fungal infections, scientists need to search for new molecules that show antimicrobial activity. However, there are various methods to determine antifungal and antimicrobial activity such as diffusion methods, bioautography methods, dilution methods and other frequently used methods. This review aims to explain the methodologies mentioned, to highlight the functioning, usage, advantages and disadvantages and to compare the techniques using different sources of the last years. Additionally, some of the currently investigated natural compounds such as essential oils, which show promising results in the medication of fungal diseases, are mentioned.
ISSN:0944-5013
1618-0623
DOI:10.1016/j.micres.2021.126867