Systemic eosinophilic disease presenting as dacryoadenitis

Eosinophilic disease with orbital involvement is rare. We present two patients with dacryoadenitis associated with local and systemic eosinophilia. A 32-year-old man presented with episodic dacryoadenitis, lower respiratory inflammation and peripheral eosinophilia. Lung and lacrimal gland biopsies d...

Full description

Saved in:
Bibliographic Details
Published in:Orbit (Amsterdam) 2023-02, Vol.42 (1), p.107-111
Main Authors: Danesh, Kayla, Cohen, Liza M, Liu, Yan, Karlin, Justin N, Rootman, Daniel B
Format: Article
Language:English
Subjects:
Adult
Churg-Strauss Syndrome - complications
Churg-Strauss Syndrome - diagnosis
Churg-Strauss Syndrome - pathology
Dacryocystitis - complications
Dacryocystitis - diagnosis
Dacryocystitis - drug therapy
Eosinophilia - complications
Eosinophilia - diagnosis
Eosinophilia - drug therapy
Granulomatosis with Polyangiitis - diagnosis
Humans
Inflammation - complications
Male
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eosinophilic disease with orbital involvement is rare. We present two patients with dacryoadenitis associated with local and systemic eosinophilia. A 32-year-old man presented with episodic dacryoadenitis, lower respiratory inflammation and peripheral eosinophilia. Lung and lacrimal gland biopsies demonstrated eosinophilic infiltrate without granuloma, necrosis, or vasculitis. He improved with oral corticosteroids and Mepolizumab, an IL-5 inhibitor. The second case involved a 33-year-old man who similarly presented with episodic dacryoadenitis, pulmonary inflammation and pain/swelling in the hands and feet. Lacrimal gland biopsy demonstrated a predominantly eosinophilic infiltrate without granuloma or vasculitis. Symptoms improved with oral corticosteroids. Although neither patient was provided a definitive diagnosis, both were determined to have an eosinophilic condition on the spectrum of eosinophilic asthma or eosinophilic granulomatosis with polyangiitis.
ISSN:0167-6830
1744-5108
DOI:10.1080/01676830.2021.1973514