Maternal high-fat diet increases anhedonic behavior and modulates hippocampal Mash1 and BDNF expression in adult offspring

•Maternal high-fat diet (HFD) led to an increased body weight in adult offspring.•HFD-offspring presented alterations in body composition and increased LDL levels.•HFD-offspring exhibited a reduced hippocampal BDNF expression.•HFD-offspring showed an increased hippocampal Mash1 expression.•HFD-offsp...

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Bibliographic Details
Published in:Neuroscience letters 2021-11, Vol.764, p.136239-136239, Article 136239
Main Authors: Curi, Haidar Tafner, Dias, Clarissa Tavares, da Luz Camargo, Maria Laura Monteiro, dos Santos Gomez, Paula, Gomes, Moisés Felipe Pereira, Beserra-Filho, José Ivo Araujo, Medeiros, Alessandra, Ribeiro, Alessandra Mussi, Simabuco, Fernando Moreira, Lambertucci, Rafael Herling, Mendes-da-Silva, Cristiano
Format: Article
Language:English
Subjects:
Anhedonia
Animals
Basic Helix-Loop-Helix Transcription Factors - analysis
Basic Helix-Loop-Helix Transcription Factors - metabolism
Brain-Derived Neurotrophic Factor - analysis
Brain-Derived Neurotrophic Factor - metabolism
Diet, High-Fat - adverse effects
Disease Models, Animal
Female
Gestational Weight Gain
Hippocampus - metabolism
Humans
Male
Maternal Nutritional Physiological Phenomena
Mice
Neurotrophins
Notch pathway
Obesogenic diet
Pregnancy
Prenatal Exposure Delayed Effects - etiology
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - psychology
Serotonergic system
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Summary:•Maternal high-fat diet (HFD) led to an increased body weight in adult offspring.•HFD-offspring presented alterations in body composition and increased LDL levels.•HFD-offspring exhibited a reduced hippocampal BDNF expression.•HFD-offspring showed an increased hippocampal Mash1 expression.•HFD-offspring demonstrated anhedonic-like behavior. The consumption of a high-fat diet (HFD) during pregnancy and perinatal periods can lead to long-term effects in the offspring central nervous system, affecting pathways related to neurogenesis and behavior, and increasing predispositions to depressive and anxiety-like behaviors. Thus, this study aimed to investigate the effects of a maternal HFD on the hippocampi of adult offspring and behaviors related to anxiety and depression. The protein and mRNA expression of the brain-derived neurotrophic factor (BDNF), Mash1, Notch1, Hes5, serotonin transporter (SERT), 5-HT1A serotonergic receptor (5-HT1A), tryptophan hydroxylase 2 (TPH2, key enzyme of serotonin synthesis), JNK and pJNK were analyzed in the hippocampi of male Swiss mice. Hippocampal serotonin levels were measured using ELISA. The lipid peroxidation, total oxidant status, total antioxidant status, and GSH/GSSG were evaluated as oxidative stress measures. For the behavioral analysis, the open field, elevated plus maze, and sucrose preference tests were used. Maternal HFD led to increased body weight in dams and their offspring, as well as altered body composition and LDL levels in the offspring. There were no alterations in oxidative stress or JNK phosphorylation. Hippocampal Mash1 and BDNF expression were altered in HFD offspring. The HFD offspring exhibited anhedonic behavior. These findings suggest that maternal HFD leads to long-term alterations in the offspring's neurotrophic systems, impairing their behavior.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2021.136239