Variations in human body water isotope composition across the United States

•Covariation of drinking water and human body water isotope values exist.•Low individual variation suggest constant isotope signal transferred to tissues.•Daily exercise and amount of fluid intake influence body water isotope values.•Body water process-based mechanistic model predicts accurately mea...

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Bibliographic Details
Published in:Forensic science international 2021-10, Vol.327, p.110990-110990, Article 110990
Main Authors: Valenzuela, Luciano O, O’Grady, Shannon P, Ehleringer, James R
Format: Article
Language:English
Subjects:
Biogeochemistry
Biometrics
Body Water
Cities
Drinking water
Fluid dynamics
Fluid intake
Food
Forensic pathology
Forensic sciences
Human body
Human tissues
Hydrogen
Isotope composition
Isotope ratios
Isotopes
Laboratories
Metabolism
Physical activity
Physical simulation
Prediction models
Predictive model
Region of origin
Respiration
Stable isotopes
Tissues
Urine
Variability
Variance analysis
Variation
Vegetarianism
Water intake
Water intakes
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Summary:•Covariation of drinking water and human body water isotope values exist.•Low individual variation suggest constant isotope signal transferred to tissues.•Daily exercise and amount of fluid intake influence body water isotope values.•Body water process-based mechanistic model predicts accurately measured values. Accurate human provenancing using stable isotopes depends directly on solid understandings of the geographic and individual factors affecting isotope variability and incorporation into human tissues. Transfer of isotopic, and therefore spatial, information between environmental water and biological tissues is mediated by the isotopic composition of body water. Thus, there is a need to study body water isotope ratios at a population level and over a large isotopic and geographic range. We evaluated oxygen (δ18Obw) and hydrogen (δ2Hbw) isotope values of body water from 72 volunteers in 10 different cities across the US, and over a 5–10-day period. We analyzed covariates (e.g., water intake, physical activity, biometrics, gender) that might explain individual stable isotope ratio variations and tested a predictive model that incorporates the δ-values of drinking water, food, and O2 as well as individual variables to predict the δ-values of body water. The individual variability in body water isotope values overtime (mean 0.3‰ for δ18Obw and 2.3‰ for δ2Hbw) was lower than the intra-city variability (mean 0.9‰ for δ18Obw and 6.9‰ for δ2Hbw). Body water isotope values differed among cities (ANOVA: δ18ObwF = 97.2, p 
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2021.110990