Genetic features of verotoxigenic Escherichia coli O157:H7 isolated from clinical cases of Argentina and Chile

We aimed to compare the genetic diversity existing in VTEC O157:H7 strains isolated from cases of human disease from Argentina and Chile. For it, 76 strains were studied in relation to the distribution of genes encoding virulence factors and subtyped by lineage-specific polymorphisms (LSPA-6), and p...

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Bibliographic Details
Published in:Microbes and infection 2022-02, Vol.24 (1), p.104883-104883, Article 104883
Main Authors: Gonzalez, Juliana, Cadona, Jimena Soledad, Zotta, Claudio Marcelo, Lavayén, Silvina, Vidal, Roberto, Padola, Nora Lía, Sanso, Andrea Mariel, Bustamante, Ana Victoria
Format: Article
Language:English
Subjects:
Argentina
Chile
Escherichia coli Infections - epidemiology
Escherichia coli O157 - genetics
Humans
O157:H7
Subtyping
Verotoxigenic Escherichia coli
Virulence Factors - genetics
Virulence genes
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Summary:We aimed to compare the genetic diversity existing in VTEC O157:H7 strains isolated from cases of human disease from Argentina and Chile. For it, 76 strains were studied in relation to the distribution of genes encoding virulence factors and subtyped by lineage-specific polymorphisms (LSPA-6), and phylogroups assignment. Our results show the almost exclusive circulation of VTEC O157:H7 isolates belonging to lineage I/II, associated with hypervirulent strains, and to the phylogroup E and, on the other hand, genetic diversity present among Argentinean and Chilean strains analyzed, mainly in relation to putative virulence determinants and nle profiles.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2021.104883