Effects of Calcium and Vitamin D Co-supplementation on the Lipid Profile: A Systematic Review and Meta-analysis

•Dyslipidemia is defined the state of having abnormal blood lipid levels.•Calcium and vitamin D co-supplementation is common and widely used.•Calcium and vitamin D co-supplementation has a beneficial effect on TC, TG and HDL-C. Calcium and vitamin D co-supplementation is common and widely used, but...

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Published in:Clinical therapeutics 2021-09, Vol.43 (9), p.274-296
Main Authors: Morvaridzadeh, Mojgan, Agah, Shahram, Alibakhshi, Pooya, Heydari, Hafez, Hoseini, Ava Sadat, Palmowski, Andriko, Toupchian, Omid, Abdollahi, Shima, Rezamand, Gholamreza, Heshmati, Javad
Format: Article
Language:English
Subjects:
Adults
Bias
Blood lipids
Calciferol
Calcium
Cardiovascular disease
Cholesterol
Clinical trials
Density
Dietary supplements
High density lipoprotein
Lipids
Meta-analysis
Middle age
Placebos
Statistical analysis
Supplements
Systematic review
Triglycerides
Vitamin D
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Summary:•Dyslipidemia is defined the state of having abnormal blood lipid levels.•Calcium and vitamin D co-supplementation is common and widely used.•Calcium and vitamin D co-supplementation has a beneficial effect on TC, TG and HDL-C. Calcium and vitamin D co-supplementation is common and widely used, but randomized, controlled trials (RCTs) have yielded inconclusive results concerning its impact on the serum lipid profile. A comprehensive literature search of Medline, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials, and clinical trial registry databases was conducted to identify placebo-controlled RCTs that were published through September 2020 and that evaluated the impact of calcium and vitamin D co-supplementation on total cholesterol (TC), triglycerides (TGs), low- and very-low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C). Standardized mean differences (SMDs) were pooled using random-effects meta-analysis models. Thirteen studies in a total of 2304 participants met the inclusion criteria. Calcium and vitamin D co-supplementation was associated with significant reductions in both TC (SMD, −0.81; 95% CI, −1.35 to –0.27; I2 = 94.6%) and TGs (SMD, –0.50; 95% CI, –0.91 to –0.08; I2 = 91.5%), and with a significant increase in HDL-C (SMD, 1.22; 95% CI, 0.60 to 1.83; I2 = 95.4%). However, calcium and vitamin D co-supplementation were not found to be associated with significantly decreased low-density lipoprotein cholesterol (SMD, –0.39; 95% CI, –0.78 to 0.01; I2 = 90.1%) or very-low-density lipoprotein cholesterol (SMD, –0.01; 95% CI, –0.70 to 0.69; I2 = 82.3%). The findings from the present systematic review and meta-analysis suggest that calcium and vitamin D co-supplementation has a beneficial effect on TC, TG, and HDL-C. Larger-scale, well-designed RCTs are needed to clarify the effect of calcium and vitamin D co-supplementation on all lipid-profile components.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2021.07.018