Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms best, while deep brain stimulation (DBS) is effective for advanced PD patients; however, side effects occur with the diminishin...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2023-04, Vol.15 (2), p.312-325
Main Authors: Ma, Yi-Fan, Lin, Yi-An, Huang, Chin-Lin, Hsu, Chih-Chieh, Wang, Sabrina, Yeh, Shih-Rung, Tsai, Ying-Chieh
Format: Article
Language:English
Subjects:
6-Hydroxydopamine
Animals
Applied Microbiology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cortex (motor)
Cortex (temporal)
Deep Brain Stimulation
Dopamine - therapeutic use
Dopamine receptors
Lactiplantibacillus plantarum
Levodopa
Levodopa - adverse effects
Mesencephalon
Microbiology
Movement disorders
Neurodegenerative diseases
Neuroprotection
Neurotransmitters
Nutrition
Oscillations
Oxidopamine - adverse effects
Parkinson Disease - drug therapy
Parkinson's disease
Protein Science
Rats
Subthalamic Nucleus - physiology
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Summary:Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms best, while deep brain stimulation (DBS) is effective for advanced PD patients; however, side effects occur with the diminishing therapeutic window. Recently, Lactiplantibacillus plantarum PS128 (PS128) was found to elevate dopamine levels in rodent brains, suggesting its potential to prevent PD. Here, the therapeutic efficacy of PS128 was examined in the 6-hydroxydopamine rat PD model. Suppression of the power spectral density of beta oscillations (beta PSD) in the primary motor cortex (M1) was recorded as the indicator of disease progression. We found that 6 weeks of daily PS128 supplementation suppressed M1 beta PSD as well as did levodopa and DBS. Long-term normalization of M1 beta PSD was found in PS128-fed rats, whereas levodopa and DBS showed only temporal effects. PS128 + levodopa and PS128 + DBS exhibited better therapeutic effects than did levodopa + DBS or either alone. Significantly improved motor functions in PS128-fed rats were correlated with normalization of M1 beta PSD. Brain tissue analyses further demonstrated the role of PS128 in dopaminergic neuroprotection and the enhanced availability of neurotransmitters. These findings suggest that psychobiotic PS128 might be used alongside conventional therapies to treat PD patients.
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-021-09828-x