Role of antimicrobial peptides in atopic dermatitis

Host defense peptides (HDPs) or antimicrobial peptides (AMPs) are short cationic amphipathic peptides of divergent sequences, which are part of the innate immune system and produced by various types of cells and tissues. The predominant role of HDPs is to respond to and protect humans against infect...

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Bibliographic Details
Published in:International journal of dermatology 2022-05, Vol.61 (5), p.532-540
Main Authors: Suwanchote, Supaporn, Waitayangkoon, Palapun, Chancheewa, Bussabong, Inthanachai, Thananya, Niwetbowornchai, Nattarika, Edwards, Steven W., Virakul, Sita, Thammahong, Arsa, Kiatsurayanon, Chanisa, Rerknimitr, Pawinee, Chiewchengchol, Direkrit
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial Peptides
Atopic dermatitis
Defensins
Dermatitis
Dermatitis, Atopic - drug therapy
Humans
Immune system
Immunomodulation
Inflammation
Innate immunity
Pathogenesis
Peptides
Sequences
Skin
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Summary:Host defense peptides (HDPs) or antimicrobial peptides (AMPs) are short cationic amphipathic peptides of divergent sequences, which are part of the innate immune system and produced by various types of cells and tissues. The predominant role of HDPs is to respond to and protect humans against infection and inflammation. Common human HDPs include defensins, cathelicidin, psoriasin, dermcidin, and ribonucleases, but these peptides may be dysregulated in the skin of patients with atopic dermatitis (AD). Current evidence suggests that the antimicrobial properties and immunomodulatory effects of HDPs are involved in AD pathogenesis, making HDPs research a promising area for predicting disease severity and developing novel treatments for AD. In this review, we describe a potential role for human HDPs in the development, exacerbation, and progression of AD and propose their potential therapeutic benefits.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.15814