Does accepted definition of Clostridioides difficile infection (CDI) severity predict poor outcomes in older adults?

Background Advanced age is an important factor affecting Clostridioides difficile infection (CDI) risk and outcome. While fever and leukocytosis are prominent findings in young individuals with CDI, they are usually blunted in the elderly. Furthermore, chronic kidney disease often exists among this...

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Bibliographic Details
Published in:Aging clinical and experimental research 2022-03, Vol.34 (3), p.583-589
Main Authors: Atamna, Alaa, Babich, Tanya, Margalit, Ili, Avni, Tomer, Ben Zvi, Haim, Raz, Noa-Eliakim, Yahav, Dafna, Bishara, Jihad
Format: Article
Language:English
Subjects:
Age
Aged
Aging
Antibiotics
Antigens
Clostridioides difficile
Clostridium Infections - diagnosis
Clostridium Infections - epidemiology
Comorbidity
Creatinine
Dementia
Geriatrics/Gerontology
Hospitalization
Hospitals
Humans
Infections
Infectious diseases
Intensive care
Internal medicine
Laboratories
Medicine
Medicine & Public Health
Mortality
Odds Ratio
Older people
Original Article
Patients
Population
Retrospective Studies
Risk Factors
Variables
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Summary:Background Advanced age is an important factor affecting Clostridioides difficile infection (CDI) risk and outcome. While fever and leukocytosis are prominent findings in young individuals with CDI, they are usually blunted in the elderly. Furthermore, chronic kidney disease often exists among this population prior to the CDI episode onset. Aim We aimed to examine whether the accepted definition of severe CDI (leukocytosis ≥ 15,000 cells/μl or serum creatinine > 1.5 mg/dl) predicts poor outcomes in the elderly. Methods All CDI hospitalized individuals between January-2013 and May-2020 were included. The study population was dichotomized into older group (≥ 65 years) and younger group (
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-021-01953-5