Clinical and epidemiological characteristics, morbidity and treatment based on the registry of acromegalic patients in Colombia: RAPACO

Describe the local characteristics, methodology and results of the registry of acromegalic patients in Colombia (RAPACO). Multicenter, retrospective study based on the registry of acromegalic patients in Colombia: RAPACO. The data collected included: demographics, diagnosis, approximate time of dise...

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Published in:Growth hormone & IGF research 2021-10, Vol.60-61, p.101425-101425, Article 101425
Main Authors: Castellanos-Bueno, Rafael, Abreu-Lomba, Alín, Buitrago-Gómez, Nathalia, Patiño-Arboleda, Marcela, Pantoja-Guerrero, Doly, Valenzuela-Rincón, Alex, Arenas-Quintero, Henry M., Franco-Betancur, Humberto I., Castellanos-Pinedo, Alejandro, Movilla-Castro, Dinett, Ocampo-Chaparro, José M., Reyes-Ortiz, Carlos A., Pinzón-Tovar, Alejandro
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - epidemiology
Acromegaly - pathology
Acromegaly - therapy
Body Height
Body Mass Index
Colombia - epidemiology
Female
Follow-Up Studies
Humans
Male
Medical therapy
Middle Aged
Morbidity
Prognosis
Quality of Life
Radiation therapy
Registries - statistics & numerical data
Registry
Retrospective Studies
Risk Factors
Surgery
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Summary:Describe the local characteristics, methodology and results of the registry of acromegalic patients in Colombia (RAPACO). Multicenter, retrospective study based on the registry of acromegalic patients in Colombia: RAPACO. The data collected included: demographics, diagnosis, approximate time of disease evolution, data on weight, height, body mass index (BMI), neck circumference (NC) abdominal circumference (AC) hip circumference (HC) and waist/hip ratio (WHR); clinical and biochemical data at the time of diagnosis, etiology, immunohistochemistry of the tumor and information related to types of treatment. Descriptive analytics were employed. A total of 201 patients (60% females) with an average age at registration of 49.5 ± 14.6 years and an average time of evolution of the disease of 6.96 ± 4.5 years. Average weight was 75.1 Kg ± 12.98, with an average BMI of 28.11 ± 4.33. The most frequent symptoms mentioned at the time of diagnosis were extremity enlargement and headache. The most frequent comorbidity was arterial hypertension in 50.3% of the cases. 78.6% of cases were caused by macroadenoma. 80.1% received surgical treatment, 77.6% were under medical treatment, of which 95.7% were receiving somatostatin analogues. 26.4% of patients were treated with radiation therapy. Of the patients who received any type of clinical treatment, only 2.5% reported biochemical control at registration. It is important to recognize the local epidemiological, clinical, biochemical and treatment characteristics in order to assist in further understanding this pathology to implement local measures to improve both the quality of life as well as the prognosis of the patients diagnosed. •First multicenter descriptive study of acromegaly in Colombia.•Includes measurements not included in other published series such as: neck circumference, abdominal circumference.•Describes findings related to tumor immunohistochemistry.•Includes demographic, clinical, diagnostic and treatment characteristics.•Favors the understanding of the disease at a local and regional level.
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2021.101425