Co‐transplantation of mesenchymal stromal cell and haploidentical hematopoietic stem cell with TCR αβ depletion in children with primary immunodeficiency syndromes

Background Haploidentical HSCT is a good option for children with PIDs lacking an HLA‐matched donor. Co‐transplantation of MSCs during haploidentical HSCT in patients with PIDs may enhance engraftment, decrease the risk of GVHD, and ensure stable donor chimerism. Methods Twenty‐seven pediatric patie...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric transplantation 2021-12, Vol.25 (8), p.e14120-n/a
Main Authors: Atay, Didem, Akcay, Arzu, Akinci, Burcu, Yenigurbuz, Fatma Demir, Ovali, Ercument, Ozturk, Gulyuz
Format: Article
Language:English
Subjects:
Busulfan
CD3 antigen
Cell lines
Child
Child, Preschool
Children
Chimerism
Female
Fludarabine
Graft Rejection
Graft vs Host Disease - prevention & control
Graft-versus-host reaction
Grafts
haploidentical HSCT
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Histocompatibility antigen HLA
Humans
Immunodeficiency
Infant
Male
Mesenchymal Stem Cell Transplantation
Mesenchyme
Morbidity
MSC
Patients
Pediatrics
Primary immunodeficiencies
Primary Immunodeficiency Diseases - therapy
primary immunodeficiency syndromes
Receptors, Antigen, T-Cell, alpha-beta - metabolism
Severe combined immunodeficiency
Stem cell transplantation
Stem cells
T cell receptors
TCR αβ depletion
Transplantation Conditioning - methods
Treosulfan
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Haploidentical HSCT is a good option for children with PIDs lacking an HLA‐matched donor. Co‐transplantation of MSCs during haploidentical HSCT in patients with PIDs may enhance engraftment, decrease the risk of GVHD, and ensure stable donor chimerism. Methods Twenty‐seven pediatric patients (median age, 1.4 years; range, .3–10.9) with PIDs undergoing thirty haploidentical HSCT with TCR αβ depletion and co‐transplantation of MSCs were enrolled to study. Most patients (73.3%) received myeloablative conditioning consisting of treosulfan or busulfan, fludarabine, and thiotepa. The median duration of follow‐up was 14.3 months (range, 1–69 months). Results Acute GVHD occurred in 7 patients (grade I‐II n = 5, grade III‐IV n = 2). Chronic GVHD was observed in only one patient. Twenty‐one patients (70.2%) had 100% donor chimerism in all cell lines including T‐cell and B‐cell lineages. Primary graft failure was observed in 7 patients (25.9%). The cumulative incidences of TRM were 20% at day 100, and 26.7% at one year and five years. Probabilities of OS were 80% at day 100, and 71.9% at 1 year and 5 years. Infants transplanted younger than 6 months of age had the highest 5‐year survival rate (85.7%). Conclusion We conclude that use of TCR αβ depleted haploidentical transplantation with MSCs may ensure a rapid engraftment rate, low incidence of significant acute and chronic GVHD, and acceptable post‐transplantation morbidity, especially in patients diagnosed with SCID and may be considered in children with PIDs. In younger patients (≤6 months), survival is comparable between HLA‐matched graft and CD3+ TCRαβ depleted HLA‐mismatched graft recipients.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.14120