Autophagy is a major metabolic regulator involved in cancer therapy resistance

Autophagy sustains cellular homeostasis and metabolism in numerous diseases. By regulating cancer metabolism, both tumor and microenvironmental autophagy promote tumor growth. However, autophagy can support cancer progression through other biological functions such as immune response regulation or c...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2021-08, Vol.36 (7), p.109528-109528, Article 109528
Main Authors: Poillet-Perez, Laura, Sarry, Jean-Emmanuel, Joffre, Carine
Format: Article
Language:English
Subjects:
Animals
Autophagy
Drug Resistance, Neoplasm
Homeostasis
Humans
Immunity
Neoplasms - drug therapy
Neoplasms - immunology
Neoplasms - pathology
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Summary:Autophagy sustains cellular homeostasis and metabolism in numerous diseases. By regulating cancer metabolism, both tumor and microenvironmental autophagy promote tumor growth. However, autophagy can support cancer progression through other biological functions such as immune response regulation or cytokine/growth factor secretion. Moreover, autophagy is induced in numerous tumor types as a resistance mechanism following therapy, highlighting autophagy inhibition as a promising target for anti-cancer therapy. Thus, better understanding the mechanisms involved in tumor growth and resistance regulation through autophagy, which are not fully understood, will provide insights into patient treatment. Poillet-Perez et al. review how both tumor and microenvironmental autophagy promote tumor growth by regulating cancer metabolism and the immune response. Moreover autophagy is induced as a cell death or resistance mechanism following therapy. Better understanding the role of autophagy and the mechanisms involved will provide insights into patient treatment.
ISSN:2211-1247
2211-1247
DOI:10.1016/j.celrep.2021.109528