Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters

Oral mucositis is an inflammation of the oral mucosa mainly resulting from the cytotoxic effect of 5-fluorouracil (5-FU). The literature shows anti-inflammatory action of l -cysteine ( l -cys) involving hydrogen sulfide (H 2 S). In view of these properties, we investigate the effect of l -cys in ora...

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Bibliographic Details
Published in:Amino acids 2021-09, Vol.53 (9), p.1415-1430
Main Authors: Fonseca, Khetyma Moreira, Macda RodriguesCosta, Dionys, da Silva, Valderlon Freitas, de Carvalho, Jelson Lina, Oliveira, Ana Patrícia, de Melo Sousa, Francisca Beatriz, Lopes, André Luis Fernandes, da Silva Martins, Conceição, de Sousa Chaves, Letícia, Nicolau, Lucas Antonio Duarte, Cerqueira, Gilberto Santos, Medeiros, Jand Venes Rolim
Format: Article
Language:English
Subjects:
5-Fluorouracil
Amino acids
Analytical Chemistry
Animals
Anti-Inflammatory Agents - pharmacology
Antimetabolites, Antineoplastic - toxicity
Antioxidants
Antioxidants - pharmacology
Biochemical Engineering
Biochemistry
Biomedical and Life Sciences
Cricetinae
Cyclooxygenase 2 - metabolism
Cyclooxygenase-2
Cysteine
Cysteine - pharmacology
Cytotoxicity
Data analysis
Fluorouracil - toxicity
Hamsters
Hydrogen sulfide
Hydrogen Sulfide - metabolism
Immunohistochemistry
Inflammation
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Inflammation - prevention & control
Life Sciences
Male
Markers
Mast cells
Mucosa
Mucositis
Neurobiology
Nitric oxide
Nitric Oxide Synthase Type II - metabolism
Nitric-oxide synthase
Original Article
Proteomics
Stomatitis - chemically induced
Stomatitis - drug therapy
Stomatitis - immunology
Stomatitis - pathology
Trauma
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Summary:Oral mucositis is an inflammation of the oral mucosa mainly resulting from the cytotoxic effect of 5-fluorouracil (5-FU). The literature shows anti-inflammatory action of l -cysteine ( l -cys) involving hydrogen sulfide (H 2 S). In view of these properties, we investigate the effect of l -cys in oral mucositis induced by 5-FU in hamsters. The animals were divided into the following groups: saline 0.9%, mechanical trauma, 5-FU 60–40 mg/kg, l -cys 10/40 mg and NaHS 27 µg/kg. 5-FU was administered on days 1st to 2nd; 4th day excoriations were made on the mucosa; 5th–6th received l -cys and NaHS. For data analysis, histological analyses, mast cell count, inflammatory and antioxidants markers, and immunohistochemistry (cyclooxygenase-2(COX-2)/inducible nitric oxide synthase (iNOs)/H 2 S) were performed. Results showed that l -cys decreased levels of inflammatory markers, mast cells, levels of COX-2, iNOS and increased levels of antioxidants markers and H 2 S when compared to the group 5-FU ( p  
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-021-03062-z