Global longitudinal strain predicts atrial fibrillation in individuals without hypertension: A Community-based cohort study

Background Global longitudinal strain (GLS) is a sensitive marker of myocardial dysfunction and atrial reservoir function. We sought to evaluate its value for predicting atrial fibrillation (AF) in the general population. Methods Participants from the Copenhagen City Heart Study examined with echoca...

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Published in:Clinical research in cardiology 2021-11, Vol.110 (11), p.1801-1810
Main Authors: Olsen, Flemming Javier, Biering-Sørensen, Sofie Reumert, Reimer Jensen, Anne Marie, Schnohr, Peter, Jensen, Gorm Boje, Svendsen, Jesper Hastrup, Møgelvang, Rasmus, Biering-Sørensen, Tor
Format: Article
Language:English
Subjects:
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Atrial Fibrillation - physiopathology
Cardiac arrhythmia
Cardiology
Cohort analysis
Denmark - epidemiology
Echocardiography
Echocardiography - methods
Female
Fibrillation
Follow-Up Studies
Humans
Hypertension
Incidence
Male
Medicine
Medicine & Public Health
Middle Aged
Original Paper
Predictive Value of Tests
Prospective Studies
Risk analysis
Risk Assessment - methods
Risk Factors
Stroke Volume - physiology
Ventricular Function, Left - physiology
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Summary:Background Global longitudinal strain (GLS) is a sensitive marker of myocardial dysfunction and atrial reservoir function. We sought to evaluate its value for predicting atrial fibrillation (AF) in the general population. Methods Participants from the Copenhagen City Heart Study examined with echocardiography, including speckle tracking analyses, were included. The endpoint was AF obtained through national registries. Proportional hazards Cox regression was applied, including multivariable adjustments made for CHADS 2 and CHARGE-AF risk factors. Abnormal GLS was defined as >—18%. Results The data from 1,309 participants were analyzed. Of those, 153 (12%) developed AF during a median follow-up time of 15.9 years. The follow-up was 100%. The mean age was 57 years, 38% had hypertension, and GLS was  − 18%. In unadjusted analysis, GLS was a univariable predictor of outcome (1.08 (1.04–1.13), p 
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-021-01921-z