Role of histone acetyltransferases MOF and Tip60 in genome stability

The accurate repair of DNA damage specifically the chromosomal double-strand breaks (DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) and radiomimetic drugs is critical in maintaining genomic integrity. The DNA DSB response and repair is facilitated by hier...

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Bibliographic Details
Published in:DNA repair 2021-11, Vol.107, p.103205, Article 103205
Main Authors: Mir, Ulfat Syed, Bhat, Audesh, Mushtaq, Arjamand, Pandita, Shruti, Altaf, Mohammad, Pandita, Tej K.
Format: Article
Language:English
Subjects:
DNA DSB repair
Histone acetylation
Histone Acetyltransferases
MOF
TIP60
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Summary:The accurate repair of DNA damage specifically the chromosomal double-strand breaks (DSBs) arising from exposure to physical or chemical agents, such as ionizing radiation (IR) and radiomimetic drugs is critical in maintaining genomic integrity. The DNA DSB response and repair is facilitated by hierarchical signaling networks that orchestrate chromatin structural changes specifically histone modifications which impact cell-cycle checkpoints through enzymatic activities to repair the broken DNA ends. Various histone posttranslational modifications such as phosphorylation, acetylation, methylation and ubiquitylation have been shown to play a role in DNA damage repair. Recent studies have provided important insights into the role of histone-specific modifications in sensing DNA damage and facilitating the DNA repair. Histone modifications have been shown to determine the pathway choice for repair of DNA DSBs. This review will summarize the role of important histone acetyltransferases MOF and Tip60 mediated acetylation in repair of DNA DSBs in eukaryotic cells.
ISSN:1568-7864
1568-7856
1568-7856
DOI:10.1016/j.dnarep.2021.103205