[68Ga]-DOTATATE PET/MRI in the diagnosis and management of recurrent head and neck paraganglioma with spinal metastasis

[68Ga]-DOTATATE PET/MRI in the diagnosis and management of recurrent head and neck paraganglioma with spinal metastasis

Most head and neck paragangliomas (PGLs) are biochemically silent and often present with recurrence and metastases in association with hereditary syndromes. Whole-body functional imaging is increasingly used to detect tumor extent and guide treatment planning of PGLs. [68Ga]-DOTATATE, which targets...

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Bibliographic Details
Published in:Clinical imaging 2021-11, Vol.79, p.314-318
Main Authors: Kim, Sean H., Roytman, Michelle, Kamen, Emily, Skafida, Myrto, Strauss, Sara, Lin, Eaton, Kutler, David, Zan, Elcin, Ivanidze, Jana
Format: Article
Language:eng
Subjects:
Catecholamines
Computed tomography
DOTATATE
Epidural
Gadolinium
Head and neck
Laboratories
Literature reviews
Lymphatic system
Magnetic resonance imaging
Medical imaging
Metastases
Metastasis
Molecular imaging
Mutation
Neck
Nuclear medicine
Paraganglioma
Patients
PET/MRI
Positron emission
Radiation
Sinuses
Somatostatin
Tomography
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Summary:Most head and neck paragangliomas (PGLs) are biochemically silent and often present with recurrence and metastases in association with hereditary syndromes. Whole-body functional imaging is increasingly used to detect tumor extent and guide treatment planning of PGLs. [68Ga]-DOTATATE, which targets somatostatin receptor 2 (SSTR2) overexpression, has emerged as a sensitive functional imaging modality in PGLs. We present a patient with metastatic glomus caroticum PGL in whom [68Ga]-DOTATATE PET/MRI provided a more accurate characterization of metastatic extent, as compared to gadolinium-enhanced MRI of the neck and whole body [18F]-FDG PET/CT. We then review the current literature and discuss the imaging implications of [68Ga]-DOTATATE PET/MRI in PGLs. •[68Ga]-DOTATATE PET targets somatostatin receptor 2 (SSTR2) overexpression in paraganglioma with great affinity.•[68Ga]-DOTATATE PET/MR allows improved delineation and treatment planning of primary neoplasm and metastases in PGLs.•Combined PET/MR imaging improves patient comfort by eliminating separate visits and reduces radiation exposure compared to PET/CT.
ISSN:0899-7071
1873-4499