Association of plasma neutrophil gelatinase-associated lipocalin with parameters of CKD–MBD in maintenance hemodialysis patients

Introduction Neutrophil gelatinase-associated lipocalin (NGAL) is not only a biomarker of kidney injury but also a bone-derived factor involved in metabolism. We aimed to explore relationships between plasma NGAL and chronic kidney disease-mineral bone disorder (CKD-MBD) parameters in maintenance he...

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Published in:Journal of bone and mineral metabolism 2021-11, Vol.39 (6), p.1058-1065
Main Authors: Jia, Xiao-yan, Wei, Kai, Chen, Juan, Xi, Lin-he, Kong, Xiang-lei, Wei, Yong, Wang, Li, Wang, Zun-song, Liu, Yi-peng, Liang, Li-ming, Xu, Dong-mei
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biomarkers
Bone diseases
Chronic Kidney Disease-Mineral and Bone Disorder
Correlation analysis
Cross-Sectional Studies
Female
Fibroblast Growth Factor-23
Gelatinase
Hemodialysis
Humans
Hyperparathyroidism
Kidney diseases
Klotho protein
Leukocytes (neutrophilic)
Lipocalin
Lipocalin-2 - blood
Medicine
Medicine & Public Health
Metabolic Diseases
Neutrophils
Original Article
Orthopedics
Parathyroid
Parathyroid hormone
Parathyroidectomy
Plasma
Renal Dialysis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - therapy
Transplantation
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Summary:Introduction Neutrophil gelatinase-associated lipocalin (NGAL) is not only a biomarker of kidney injury but also a bone-derived factor involved in metabolism. We aimed to explore relationships between plasma NGAL and chronic kidney disease-mineral bone disorder (CKD-MBD) parameters in maintenance hemodialysis (MHD) patients. Materials and methods First, a cross sectional observational study, including 105 MHD patients, was conducted to explore relationships between plasma NGAL levels and CKD–MBD parameters. Second, impact of parathyroidectomy and auto-transplantation (PTX + AT) on plasma NGAL was investigated in 12 MHD patients with severe secondary hyperparathyroidism (SHPT). Results According to Spearman correlation analysis, plasma NGAL levels were positively correlated with female ( r  = 0.243, P  = 0.012), vintage ( r  = 0.290, P  = 0.003), Klotho ( r  = 0.234, P  = 0.016), calcium(Ca) ( r  = 0.332, P  = 0.001), alkaline phosphatase (ALP) ( r  = 0.401, P  
ISSN:0914-8779
1435-5604
DOI:10.1007/s00774-021-01248-9