Increased risk of Barrett’s oesophagus and related neoplasia in individuals with a positive family history

Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesoph...

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Bibliographic Details
Published in:European journal of cancer (1990) 2021-09, Vol.155, p.116-126
Main Authors: Peters, Yonne, Huibertse, Lotte J., Schrauwen, Ruud W.M., Tan, Adriaan C., van der Post, Rachel S., Siersema, Peter D.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Aged
Barrett Esophagus - diagnosis
Barrett Esophagus - physiopathology
Barrett's esophagus
Barrett’s oesophagus
Body mass
Body mass index
Body size
Case-Control Studies
Clustering
Detection
Esophageal cancer
Family history
Family size
Female
Gastroesophageal reflux
Genetics
Histopathology
Humans
Male
Medical History Taking - methods
Middle Aged
Oesophageal cancer
PALGA
Population control
Risk analysis
Risk Factors
Surveys and Questionnaires
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Summary:Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention strategies. We aimed to determine whether individuals with a positive family history of Barrett’s oesophagus (BE) and EAC are at an increased risk of oesophageal neoplasia. In a multi-centre case–control study, BE patients with or without related oesophageal neoplasia and randomly selected population controls filled out a questionnaire to collect information on family history and other risk factors for BE and EAC. Positive family history was defined as having ≥1 first-degree relative with BE or EAC whose diagnosis was histologically confirmed in the Dutch nationwide histopathology database. We included 480 BE patients and 420 controls without BE who had a total of 6393 first-degree relatives. A pathologically confirmed positive family history was significantly higher in BE patients compared with controls (6.5% versus 0.9; p 
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2021.07.007