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Influence of doxapram and intermittent 10% carbon dioxide inspiration on cardiovascular and laryngeal functions in anesthetized dogs
Objective To compare the effects of two doses of doxapram intravenous injection and carbon dioxide inhalation on the cardiovascular and laryngeal functions of anesthetized hounds. Study Design Experimental study. Animals Six healthy adult dogs. Methods In a Latin‐square design, the mean arterial blo...
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Published in: | Veterinary surgery 2021-10, Vol.50 (7), p.1418-1426 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objective
To compare the effects of two doses of doxapram intravenous injection and carbon dioxide inhalation on the cardiovascular and laryngeal functions of anesthetized hounds.
Study Design
Experimental study.
Animals
Six healthy adult dogs.
Methods
In a Latin‐square design, the mean arterial blood pressure (MABP) and heart rate (HR) were recorded continuously. The inspiratory normalized glottic gap areas (iNGGA) were measured before and after each stimulation with 0.55 mg/kg of doxapram (L‐DOX), 2.2 mg/kg of doxapram (H‐DOX), or 90 s of inhalation of 10% carbon dioxide in oxygen (I‐CO2). The stimulations were tested in duplicate or triplicate. Video clips of the laryngeal movement were scored by board‐certified surgeons masked to the treatment.
Results
The MABP increased with L‐DOX and H‐DOX up to 81% (both p |
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ISSN: | 0161-3499 1532-950X |
DOI: | 10.1111/vsu.13709 |