Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome

Excessive prenatal opioid exposure may lead to the development of Neonatal Opioid Withdrawal Syndrome (NOWS). RNA-seq was done on 64 formalin-fixed paraffin-embedded placental tissue samples from 32 mothers with opioid use disorder, with newborns with NOWS that required treatment, and 32 prenatally...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2021-11, Vol.113 (6), p.3610-3617
Main Authors: Radhakrishna, Uppala, Nath, Swapan K., Vishweswaraiah, Sangeetha, Uppala, Lavanya V., Forray, Ariadna, Muvvala, Srinivas B., Mishra, Nitish K., Southekal, Siddesh, Guda, Chittibabu, Govindamangalam, Hiranjith, Vargas, Derek, Gardella, William G., Crist, Richard C., Berrettini, Wade H., Metpally, Raghu P., Bahado-Singh, Ray O.
Format: Article
Language:English
Subjects:
Analgesics, Opioid - therapeutic use
Carrier Proteins
Differentially expressed genes
Female
Gene Expression Profiling
Humans
In utero drug exposure
Infant
Infant, Newborn
Membrane Proteins
Neonatal abstinence syndrome
Neonatal Abstinence Syndrome - complications
Neonatal Abstinence Syndrome - drug therapy
Neonatal Abstinence Syndrome - genetics
Opioid-Related Disorders - drug therapy
Opioid-Related Disorders - genetics
Placenta
Pregnancy
Transcription factors
Transcriptional regulatory element
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Summary:Excessive prenatal opioid exposure may lead to the development of Neonatal Opioid Withdrawal Syndrome (NOWS). RNA-seq was done on 64 formalin-fixed paraffin-embedded placental tissue samples from 32 mothers with opioid use disorder, with newborns with NOWS that required treatment, and 32 prenatally unexposed controls. We identified 93 differentially expressed genes in the placentas of infants with NOWS compared to unexposed controls. There were 4 up- and 89 downregulated genes. Among these, 7 genes CYP1A1, APOB, RPH3A, NRXN1, LINC01206, AL157396.1, UNC80 achieved an FDR p-value of
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2021.08.001