Clinical and histopathological evaluation of 50 acantholytic cutaneous squamous cell carcinomas: Analysis outcome in a retrospective case‐control study

Background Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high‐risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of...

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Published in:Journal of cutaneous pathology 2022-02, Vol.49 (2), p.133-138
Main Authors: Conde‐Ferreirós, Alberto, Moyano‐Bueno, David, Santos‐Briz, Ángel, Revelles‐Peñas, Leonor, Revilla‐Nebreda, David, Becerril‐Andrés, Sara, Román‐Curto, Concepción, Cañueto, Javier
Format: Article
Language:English
Subjects:
acantholytic squamous cell carcinoma
Aged, 80 and over
Carcinoma, Squamous Cell - pathology
Case-Control Studies
cutaneous squamous cell carcinoma
Female
Growth patterns
Head and neck
Humans
Lymph nodes
Lymphatic Metastasis
Male
Margins of Excision
Metastases
Neoplasm Recurrence, Local
Prognosis
Retrospective Studies
skin cancer
Skin Neoplasms - pathology
Squamous cell carcinoma
Tumors
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Summary:Background Acantholytic cutaneous squamous cell carcinomas (aCSCCs) have been classically considered as a high‐risk variant of CSCC. However, more recent studies show that aCSCC does not confer more aggressiveness. This study aims to establish whether the prognosis of the aCSCC is worse than that of the non‐acantholytic (naCSCC) or not. Methods Retrospective case‐control study with 50 aCSCCs and 50 naCSCCs. For each aCSCC, an naCSCC with similar high‐risk features to the aCSCC but with no acantholysis was selected. Prognosis between both groups was compared. Results The mean age was 86 years (SD 9.61). Sixty‐one patients were men. Thirty‐nine CSCCs were located in high‐risk head and neck areas. Twenty CSCCs exhibited a poor degree of differentiation, and 36 showed an infiltrative growth pattern. The tumor diameter was 18.71 mm (interquartile range, IQR 35), and the tumor thickness was 6.72 mm (IQR 15.50). Twelve CSCCs exhibited perineural infiltration, and eight CSCCs exhibited invasion beyond the subcutaneous fat. Positive margins after excision of the tumor in 22 aCSCCs vs eight naCSCCs (P 
ISSN:0303-6987
1600-0560
DOI:10.1111/cup.14116