Effects of body weight regain on leptin levels: A systematic review and meta-analysis

•Weight loss and regain leads to several physiological and metabolic changes.•Leptinis an adipocyte-secreted hormone inhibiting food intake and stimulating energy expenditure.•Body weight regain may be related to an increase in blood leptin levels. There are different changes observed before and aft...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2021-12, Vol.148, p.155647-155647, Article 155647
Main Authors: Rostami Rayeni, Najme, Abdollahzad, Hadi, Alibakhshi, Pooya, Morvaridzadeh, Mojgan, Heydari, Hafez, Dehnad, Afsaneh, Khorshidi, Masoud, Izadi, Azimeh, Shidfar, Farzad, Dulce Estêvão, M., Omidi, Amirhosein, Heshmati, Javad
Format: Article
Language:English
Subjects:
Adult
BMI
Humans
Leptin
Leptin - blood
Publication Bias
Risk
Systematic review, hormonal changes?
Weight Gain - physiology
Weight regain
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Summary:•Weight loss and regain leads to several physiological and metabolic changes.•Leptinis an adipocyte-secreted hormone inhibiting food intake and stimulating energy expenditure.•Body weight regain may be related to an increase in blood leptin levels. There are different changes observed before and after diet therapy, and also after weight regain. However, there is not sufficient information regarding weight regain and hormonal changes. The purpose of this study was to review the connection between weight regain and leptin concentration levels. MEDLINE, SCOPUS, Web of Science, and the Cochrane Library were searched for interventional articles published from January 1, 1980, to June 30, 2020. Randomized clinical trials with parallel or cross over design assessing leptin concentrations at the baseline and at the end of study were reviewed. Two independent reviewers extracted data related to study design, year of publication, country, age, gender, body mass index (BMI), duration of the following up period and mean ± SD of other intended variables. Four articles were included, published between 2004 and 2016. Three of them were conducted in the US and one of them in Netherland. Sample size of the studies ranged between 25 and 148 participants. The range of following up period was from13 to 48 weeks. The age range of participants was from 34 to 44 years. Our analysis shows that weight regain could reduce leptin levels, but this change is not statistically significant. This review suggests that weight regain may induce a non-significant reduction in leptin level. However, the limited number and great heterogeneity between the included studies may affect the presented results and there are still need to well-designed, large population studies to determine the relationship between weight regain and leptin levels.
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2021.155647