Resting-state functional MRI language network connectivity differences in patients with brain tumors: exploration of the cerebellum and contralesional hemisphere

Brain tumors can have far-reaching impacts on functional networks. Language processing is typically lateralized to the left hemisphere, but also involves the right hemisphere and cerebellum. This resting-state functional MRI study investigated the proximal and distal effects of left-hemispheric brai...

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Bibliographic Details
Published in:Brain imaging and behavior 2022-02, Vol.16 (1), p.252-262
Main Authors: Cho, Nicholas S., Peck, Kyung K., Gene, Madeleine N., Jenabi, Mehrnaz, Holodny, Andrei I.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Brain
Brain cancer
Brain Mapping
Brain Neoplasms - diagnostic imaging
Brain tumors
Cerebellum
Cerebellum - diagnostic imaging
Functional magnetic resonance imaging
Hemispheres
Hemispheric laterality
Homology
Humans
Language
Magnetic Resonance Imaging
Natural language processing
Neural networks
Neurological diseases
Neuropsychology
Neuroradiology
Neurosciences
Original Research
Protein seeding
Psychiatry
Tumors
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Summary:Brain tumors can have far-reaching impacts on functional networks. Language processing is typically lateralized to the left hemisphere, but also involves the right hemisphere and cerebellum. This resting-state functional MRI study investigated the proximal and distal effects of left-hemispheric brain tumors on language network connectivity in the ipsilesional and contralesional hemispheres. Separate language resting-state networks were generated from seeding in ipsilesional (left) and contralesional (right) Broca’s Area for 29 patients with left-hemispheric brain tumors and 13 controls. Inclusion criteria for all subjects included language left-dominance based on task-based functional MRI. Functional connectivity was analyzed in each network to the respective Wernicke’s Area and contralateral cerebellum. Patients were assessed for language deficits prior to scanning. Compared to controls, patients exhibited decreased connectivity in the ipsilesional and contralesional hemispheres between the Broca’s Area and Wernicke’s Area homologs (mean connectivity for patients/controls: left 0.51/0.59, p  
ISSN:1931-7557
1931-7565
DOI:10.1007/s11682-021-00498-5