Oxygen-glucose deprivation in neurons: implications for cell transplantation therapies

•Many cells die soon after transplantation to the brain.•An initial paucity of nutrients for the grafted cells is likely.•In vitro Stroke models elucidate the relative importance of glucose vs oxygen.•Suppling glucose to the graft may improve cell survival and functional outcomes. Cell replacement t...

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Bibliographic Details
Published in:Progress in neurobiology 2021-10, Vol.205, p.102126-102126, Article 102126
Main Authors: Rizzo, Sebastiano Antonio, Bartley, Oliver, Rosser, Anne E., Newland, Ben
Format: Article
Language:English
Subjects:
cell therapies
Cell Transplantation
Glucose
graft survival
Humans
Huntington Disease
ischemia
neurodegenerative diseases
neuronal anaerobic glycolysis
Neurons
Oxygen
Stem Cell Transplantation
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Summary:•Many cells die soon after transplantation to the brain.•An initial paucity of nutrients for the grafted cells is likely.•In vitro Stroke models elucidate the relative importance of glucose vs oxygen.•Suppling glucose to the graft may improve cell survival and functional outcomes. Cell replacement therapies hold the potential to restore neuronal networks compromised by neurodegenerative diseases (such as Parkinson’s disease or Huntington’s disease), or focal tissue damage (via a stroke or spinal cord injury). Despite some promising results achieved to date, transplanted cells typically exhibit poor survival in the central nervous system, thus limiting therapeutic efficacy of the graft. Although cell death post-transplantation is likely to be multifactorial in causality, growing evidence suggests that the lack of vascularisation at the graft site, and the resulting ischemic host environment, may play a fundamental role in the fate of grafted cells. Herein, we summarise data showing how the deprivation of either oxygen, glucose, or both in combination, impacts the survival of neurons and review strategies which may improve graft survival in the central nervous system.
ISSN:0301-0082
1873-5118
DOI:10.1016/j.pneurobio.2021.102126