Clinical significance and prognostic value of circulating B10 cells in colorectal cancer

Background B10 cells, a subset of regulatory B cells, can inhibit antitumor response and thus promote tumor development. This study explored the clinical meaning and prognostic value of circulating B10 cells in colorectal cancer (CRC). Materials and methods The proportion of B10 cells in peripheral...

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Bibliographic Details
Published in:Asia-Pacific journal of clinical oncology 2022-04, Vol.18 (2), p.e157-e162
Main Authors: Qiu, Zhaoyan, Li, Qian, Lu, Yixun, Wang, Qian
Format: Article
Language:English
Subjects:
Antitumor activity
B10 cells
Biomarkers, Tumor
CD19 antigen
Clinical significance
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - pathology
Flow cytometry
Humans
Kaplan-Meier Estimate
Lymph nodes
Lymphatic Metastasis
Lymphocytes B
Metastases
Multivariate analysis
Neoplasm Staging
Patients
Peripheral blood
Prognosis
Tumors
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Summary:Background B10 cells, a subset of regulatory B cells, can inhibit antitumor response and thus promote tumor development. This study explored the clinical meaning and prognostic value of circulating B10 cells in colorectal cancer (CRC). Materials and methods The proportion of B10 cells in peripheral blood in CRC patients and healthy controls was detected by multicolor flow cytometry. Results The proportion of circulating B10 cells was remarkably elevated in CRC patients compared to normal controls (% of CD19+B cells; 16.6% (IQR 6.0%) versus 9.0% (IQR 5.7%), p < 0.001). B10 cells proportion was associated with tumor size, depth of invasion, lymph node metastasis, and TNM stage in CRC. Kaplan–Meier analysis indicated that CRC patients with high B10 cells proportion suffered worse overall survival than those with low B10 cells proportion. Multivariate analysis revealed that the proportion of B10 cells was an independent prognostic indicator for CRC patients. Conclusion Our results indicate that the proportion of circulating B10 cells is an independent prognostic factor for patients with CRC and thus may help guide the clinical decision in CRC. Proportion of circulating B10 cells is increased in peripheral blood of CRC patients and associated with poor prognosis.
ISSN:1743-7555
1743-7563
DOI:10.1111/ajco.13586