Parasite protein phosphatases: biological function, virulence, and host immune evasion

Protein phosphatases are enzymes that dephosphorylate tyrosine and serine/threonine amino acid residues. Although their role in cellular processes has been best characterized in higher eukaryotes, they have also been identified and studied in different pathogenic microorganisms (e.g., parasites) in...

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Bibliographic Details
Published in:Parasitology research (1987) 2021-08, Vol.120 (8), p.2703-2715
Main Authors: Gómez-Sandoval, Jenny Nancy, Escalona-Montaño, Alma Reyna, Navarrete-Mena, Abril, Aguirre-García, M. Magdalena
Format: Article
Language:English
Subjects:
Amino acids
B cells
Biomedical and Life Sciences
Biomedicine
Cell cycle
Drug therapy
Enzymes
Immune evasion
Immune response
Immunology
Immunology and Host-Parasite Interactions - Review
Mammalian cells
Medical Microbiology
Microbiology
Parasites
Phosphatase
Phosphatases
Physiological aspects
Proteins
Serine
Structure-function relationships
Threonine
Tyrosine
Virulence
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Summary:Protein phosphatases are enzymes that dephosphorylate tyrosine and serine/threonine amino acid residues. Although their role in cellular processes has been best characterized in higher eukaryotes, they have also been identified and studied in different pathogenic microorganisms (e.g., parasites) in the last two decades. Whereas some parasite protein phosphatases carry out functions similar to those of their homologs in yeast and mammalian cells, others have unique structural and/or functional characteristics. Thus, the latter unique phosphatases may be instrumental as targets for drug therapy or as markers for diagnosis. It is important to better understand the involvement of protein phosphatases in parasites in relation to their cell cycle, metabolism, virulence, and evasion of the host immune response. The up-to-date information about parasite phosphatases of medical and veterinarian relevance is herein reviewed.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-021-07259-9