Solid-gas reactions for nitroxyl (HNO) generation in the gas phase

We present a novel nitroxyl (HNO) generation method, which avoids the need of using a liquid system or extreme experimental conditions. This method consists of the reaction between a gaseous base and an HNO donor (Piloty’s acid) in the solid phase, allowing the formation of gaseous HNO in a fast and...

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Bibliographic Details
Published in:Journal of inorganic biochemistry 2021-10, Vol.223, p.111535-111535, Article 111535
Main Authors: Carrone, Guillermo, Mazzeo, Agostina, Marceca, Ernesto, Pellegrino, Juan, Suárez, Sebastián, Zarenkiewicz, Jessica, Toscano, John P., Doctorovich, Fabio
Format: Article
Language:English
Subjects:
Ammonia - chemistry
Gaseous
Gases - chemistry
HNO
Hydroxamic Acids - chemistry
Nitrogen Oxides - chemical synthesis
Nitroxyl
Piloty's acid
Sulfonamides - chemistry
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Summary:We present a novel nitroxyl (HNO) generation method, which avoids the need of using a liquid system or extreme experimental conditions. This method consists of the reaction between a gaseous base and an HNO donor (Piloty’s acid) in the solid phase, allowing the formation of gaseous HNO in a fast and economical way. Detection of HNO was carried out indirectly, measuring the nitrous oxide (N2O) byproduct of HNO dimerization using infrared spectroscopy, and directly, using mass spectrometry techniques and an electrochemical HNO sensor. [Display omitted] •A novel method for HNO production in the gas phase is described.•The method consists of heterogeneous reactions between solid HNO donors and gaseous NH3.•This method can be useful for chemical studies and medical applications.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2021.111535