Neuroprotective and antioxidant effect of Curcuma longa (Rhizome) methanolic extract on SH-SY5Y cells and Javanese medaka

Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in high demand. Therefore, the main purposed of this study is to evaluate the neur...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2021-01, Vol.34 (1), p.47-56
Main Authors: Hassan, Ibrahim Maina, Wan Ibrahim, Wan Norhamidah, Yusuf, Ferdaus Mohamat, Ahmad, Siti Aqlima, Ahmad, Syahida
Format: Article
Language:English
Subjects:
Alternative medicine
Animals
Antioxidants
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biological products
Care and treatment
Cell Survival - drug effects
Cell Survival - physiology
Curcuma
Dose-Response Relationship, Drug
Humans
Nervous system diseases
Neuroprotective Agents - isolation & purification
Neuroprotective Agents - pharmacology
Oryzias
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rhizome
Type 2 diabetes
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Summary:Diseases caused by oxidative stress can be prevented by antioxidant. Current treatments for those neurodegenerative diseases are not effective and cause many side effects. Thus, the search for alternative medicines is in high demand. Therefore, the main purposed of this study is to evaluate the neuroprotective effects of Curcuma longa (rhizome) 80% methanol extract. Antioxidant using dichlorofuoresence diacetate (DCF-DA) assay on SH-SY5Y cells revealed high activities of Curcuma longa (rhizome) extract with IC50 of 105.9±0.8 µg/mL. Sub-acute and chronic toxicity tests of the plant extract on adult Javanese medaka (Oryzias javanicus) showed high toxicity effect with LC of 24.15±0.8 mg/L and 13.69±0.7 mg/L respectively. Neuroprotective tests using cholinesterase assay disclose significant differences at P
ISSN:1011-601X
DOI:10.36721/PJPS.2021.34.1.REG.047-056.1