HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study

Abstract Aims Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether HIV status is independently associated with having aortic aneurysms. Furthermore, we determined risk factors associated with aortic aneurysms in PLWH. Methods and resul...

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Published in:European heart journal 2021-08, Vol.42 (30), p.2924-2931
Main Authors: Høgh, Julie, Pham, Michael Huy Cuong, Knudsen, Andreas Dehlbæk, Thudium, Rebekka Faber, Gelpi, Marco, Sigvardsen, Per Ejlstrup, Fuchs, Andreas, Kühl, , Jørgen Tobias, Afzal, Shoaib, Nordestgaard, Børge Grønne, Benfield, Thomas, Køber, Lars, Gerstoft, Jan, Kofoed, Klaus Fuglsang, Nielsen, Susanne Dam
Format: Article
Language:English
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Summary:Abstract Aims Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether HIV status is independently associated with having aortic aneurysms. Furthermore, we determined risk factors associated with aortic aneurysms in PLWH. Methods and results PLWH aged ≥40 years (n = 594) were recruited from the Copenhagen Comorbidity in HIV Infection study and matched for age and sex with uninfected controls (n = 1188) from the Copenhagen General Population Study. Aortic dimensions were assessed using contrast enhanced computed tomography. Aortic aneurysms were defined according to the European Society of Cardiology guidelines, i.e. an aortic dilation of ≥50% or an infrarenal aortic diameter of ≥30 mm. Among PLWH and uninfected controls, the median (interquartile range) age was 52 (47–60) and 52 (48–61) and 88% and 90% were male, respectively. We found 46 aneurysms in 42 (7.1%) PLWH and 31 aneurysms in 29 (2.4%) uninfected controls (P 
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehab348