Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid–base balance

Abstract Background Metabolic acidosis occurs frequently in patients with kidney transplant and is associated with a higher risk for and accelerated loss of graft function. To date, it is not known whether alkali therapy in these patients improves kidney function and whether acidosis and its therapy...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2021-10, Vol.36 (10), p.1806-1820
Main Authors: Imenez Silva, Pedro H, Wiegand, Anna, Daryadel, Arezoo, Russo, Giancarlo, Ritter, Alexander, Gaspert, Ariana, Wüthrich, Rudolf P, Wagner, Carsten A, Mohebbi, Nilufar
Format: Article
Language:English
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Summary:Abstract Background Metabolic acidosis occurs frequently in patients with kidney transplant and is associated with a higher risk for and accelerated loss of graft function. To date, it is not known whether alkali therapy in these patients improves kidney function and whether acidosis and its therapy are associated with altered expression of proteins involved in renal acid–base metabolism. Methods We retrospectively collected kidney biopsies from 22 patients. Of these patients, nine had no acidosis, nine had metabolic acidosis [plasma bicarbonate (HCO3− 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfab210