Brain-derived neurotrophic factor in blood serum and lacrimal fluid of patients with focal epilepsy

•In patients with focal epilepsy, BDNF level is decreased both in blood serum and lacrimal fluid.•No association of BDNF levels with age and epilepsy characteristics, as well as the occurrence of depression, was found.•Low BDNF level in lacrimal fluid could be considered as a non-invasive biomarker...

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Bibliographic Details
Published in:Epilepsy research 2021-10, Vol.176, p.106707-106707, Article 106707
Main Authors: Shpak, Alexander A., Guekht, Alla B., Druzhkova, Tatiana A., Rider, Flora K., Gulyaeva, Natalia V.
Format: Article
Language:English
Subjects:
Blood serum
Brain-Derived Neurotrophic Factor
Case-Control Studies
Epilepsies, Partial
Female
Focal epilepsy
Humans
Lacrimal fluid
Male
Non-invasive biomarkers
People with epilepsy
Serum
Tears
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Summary:•In patients with focal epilepsy, BDNF level is decreased both in blood serum and lacrimal fluid.•No association of BDNF levels with age and epilepsy characteristics, as well as the occurrence of depression, was found.•Low BDNF level in lacrimal fluid could be considered as a non-invasive biomarker of focal epilepsy. To evaluate brain-derived neurotrophic factor (BDNF) level in blood serum (BS) and lacrimal fluid (LF) of people with epilepsy (PWE). It was a case-control study of 72 consecutive patients with focal epilepsy (cases, Epilepsy group) and 60 age- and gender-matched healthy volunteers (controls). Based on comorbid depression, two subgroups of PWE were formed. BDNF level was measured by enzyme-linked immunosorbent assay (ELISA) in BS and LF. Compared to controls, BDNF level (pg/mL) in PWE was lower both in BS (22,520 ± 3810 vs. 26,360 ± 3090, P < 0.000) and in LF (100.8 ± 23.3 vs. 113.4 ± 19.3, P = 0.001). However, no significant correlation was found between BDNF level in BS and LF either in the Epilepsy group or in controls. No impact of comorbid depression on BDNF level was found either in BS or LF of PWE. We revealed a higher BDNF level in LF of men as compared to women in controls and a similar non-significant trend in PWE. Higher BDNF level in BS of PWE receiving valproates versus other AEDs was found, however, a relatively small number of observations and use of polytherapy in most cases should be taken into account. In patients with focal epilepsy, BDNF level is decreased both in BS and LF, though with no correlation between them. No association of BDNF levels with age and epilepsy characteristics, as well as the occurrence of depression, was found. Low BDNF level in LF could be considered as a non-invasive biomarker of focal epilepsy.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2021.106707