Antimicrobial and antioxidant activities of secondary metabolites from endophytic fungus Botryosphaeria fabicerciana (MGN23-3) associated to Morus nigra L

This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra. The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum...

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Bibliographic Details
Published in:Natural product research 2022-06, Vol.36 (12), p.3158-3162
Main Authors: Silva, Angela Aparecida da, Polonio, Julio Cesar, Bulla, Aline Maria, Polli, Andressa Domingos, Castro, Juliana Cristina, Soares, Lilian Capelari, Oliveira-Junior, Verci Alves de, Vicentini, Veronica Elisa Pimenta, Oliveira, Arildo José Braz de, Gonçalves, José Eduardo, Gonçalves, Regina Aparecida Correia, Azevedo, João Lúcio, Abreu-Filho, Benício Alves de, Pamphile, João Alencar
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antioxidants
Bacteria
Biological activity
Botryosphaeria
Cytotoxicity
Endophytes
Fungi
Gram-positive bacteria
Metabolites
Minimum inhibitory concentration
Morus nigra
Secondary metabolites
Toxicity
Volatile compounds
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Summary:This study was to evaluate the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra. The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was observed against Gram-positive bacteria, with a MIC of 15.6 μg/mL towards B. cereus and MIC of 62.5 μg/mL towards S. aureus and B. subtilis. MBC values of 31.25 μg/mL, 62.5 μg/mL, and 250 μg/mL were observed towards B. cereus, B. subtilis, and S. aureus, respectively. The cytotoxicity analyses showed CC50 of 115 μg/mL. The crude extract showed antioxidant activity by the DPPH, ABTS, and FRAP assays. Therefore, the extract of the endophytic fungus presented biotechnological potential as an antibacterial and antioxidant agent.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1947272