Plasma levels of nerve growth factor in Egyptian autistic children: Relation to hyperserotonemia and autoimmunity

Hyperserotonemia and brain-specific autoantibodies are detected in some autistic children. Nerve growth factor (NGF) stimulates the proliferation of B lymphocytes with production of antibodies and also increases mast cell serotonin release. This work was the first to investigate the relationship bet...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimmunology 2021-09, Vol.358, p.577638-577638, Article 577638
Main Authors: Mostafa, Gehan Ahmed, Meguid, Nagwa Abdel, Shehab, Abeer Al Sayed, Elsaeid, Amal, Maher, Mahmoud
Format: Article
Language:English
Subjects:
Anti-MBP auto-antibodies
Autism
Autistic Disorder - blood
Autistic Disorder - diagnosis
Autistic Disorder - epidemiology
Autoantibodies - blood
Autoimmunity
Autoimmunity - physiology
Biomarkers - blood
Child
Child, Preschool
Cross-Sectional Studies
Egypt
Female
Follow-Up Studies
Humans
Male
Nerve growth factor
Nerve Growth Factor - blood
Serotonin
Serotonin - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyperserotonemia and brain-specific autoantibodies are detected in some autistic children. Nerve growth factor (NGF) stimulates the proliferation of B lymphocytes with production of antibodies and also increases mast cell serotonin release. This work was the first to investigate the relationship between plasma NGF and both hyperserotonemia and the frequency of serum anti-myelin basic protein (anti-MBP) auto-antibodies in 22 autistic children aged between 4 and 12 years and 22 healthy-matched controls. Levels of NGF, serotonin and anti-MBP were significantly higher in autistic children than healthy control children (P 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2021.577638