Longitudinal variance of Donor‐Derived Cell‐Free DNA (dd‐cfDNA) in Stable Kidney Transplant (KTx) patients are influenced by donor/recipient variables

Background The longitudinal time‐course of dd‐cfDNA after kidney transplant (KTx) is not well‐described. The cut off values of dd‐cfDNA in KTx derive from biopsy‐coupled single measurements. Meaningful interpretation necessitates understanding of: (1) time variance of dd‐cfDNA levels post‐KTx, (2) f...

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Bibliographic Details
Published in:Clinical transplantation 2021-09, Vol.35 (9), p.e14395-n/a
Main Authors: Anand, Sanjiv, Lopez‐Verdugo, Fidel, Sanchez‐Garcia, Jorge, Dong, Li, Fife, Megan, Krong, Jake, Morris, Donald, Srinivas, Titte R.
Format: Article
Language:English
Subjects:
biomarker
DNA
immune
molecular biology
monitoring
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Summary:Background The longitudinal time‐course of dd‐cfDNA after kidney transplant (KTx) is not well‐described. The cut off values of dd‐cfDNA in KTx derive from biopsy‐coupled single measurements. Meaningful interpretation necessitates understanding of: (1) time variance of dd‐cfDNA levels post‐KTx, (2) factors determining biologic variability, and (3) relationship to donor and recipient characteristics. We hypothesized that an understanding of the aforementioned factors would better inform clinical decision‐making using dd‐cfDNA. Methods One hundred and twenty five KTx patients with dd‐cfDNA obtained longitudinally were included. Univariate analyses were directed at inter‐patient variability and intra‐patient inter‐occasion variability of dd‐cfDNA. Multivariate linear regression was used in analyses accounting for repeat measures. Results At 1‐month post KTx median dd‐cfDNA: (1) were higher in repeat KTx (.57%, P 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14395