Pupil constriction via the parasympathetic pathway precedes perceptual switch of ambiguous stimuli

Perceptual rivalry of ambiguous stimuli reflects the interaction of neural activity among multiple cortical regions. However, it remains unclear what drives a spontaneous perceptual alteration. We hypothesized that increased fluctuations in spontaneous neural activity due to arousal reduction drive...

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Bibliographic Details
Published in:International journal of psychophysiology 2021-09, Vol.167, p.15-21
Main Authors: Nakano, Tamami, Ichiki, Arata, Fujikado, Takashi
Format: Article
Language:English
Subjects:
Arousal
Autonomic
Bistable perception
Nervous system
Parasympathetic pathway
Pupillometry
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Summary:Perceptual rivalry of ambiguous stimuli reflects the interaction of neural activity among multiple cortical regions. However, it remains unclear what drives a spontaneous perceptual alteration. We hypothesized that increased fluctuations in spontaneous neural activity due to arousal reduction drive the perceptual switch. Here, we show that the pupils shrank a few seconds prior to the onset of the spontaneous perceptual switch. Such pupil constriction was not observed before the exogenous perceptual switch. Pharmacological experiments confirmed that the pupil constriction disappeared when the peripheral parasympathetic pathway (pupil sphincter muscle) was blocked, but it remained intact when the peripheral sympathetic pathway (pupil dilator muscle) was manipulated. Furthermore, rapid pupil dilations with behavioral response are also mediated by the peripheral parasympathetic pathway. The present findings suggested that transient arousal drops, as denoted by the autonomic nervous modulation of pupil size, are involved in inducing the spontaneous perceptual switch of bistable stimuli. •Pupils transiently shrank prior to the spontaneous perceptual switch.•Pupil constriction disappeared when the iris sphincter muscle was blocked.•It was not inhibited when the iris dilator muscle was blocked.•Transient arousal drops are involved in inducing perceptual switch of bistable stimuli.
ISSN:0167-8760
1872-7697
DOI:10.1016/j.ijpsycho.2021.06.006