From Folding to Assembly: Functional Supramolecular Architectures of Peptides Comprised of Non‐Canonical Amino Acids

The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well‐defined nanostructures with controlled size and dimensions. Short pepti...

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Bibliographic Details
Published in:Macromolecular bioscience 2021-08, Vol.21 (8), p.e2100090-n/a
Main Authors: Misra, Rajkumar, Rudnick‐Glick, Safra, Adler‐Abramovich, Lihi
Format: Article
Language:English
Subjects:
Amino acids
Amino Acids - chemistry
Assemblies
Assembling
Biocompatibility
crystallography
foldamers
hybrid peptides
Nanostructure
Nanostructures - chemistry
Nanotechnology
non‐natural amino acids
Oligomers
Peptides
Peptides - chemistry
Protein Structure, Secondary
Proteins
supramolecular assembly
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Summary:The engineering of biological molecules is the fundamental concept behind the design of complex materials with desirable functions. Over the last few decades, peptides and proteins have emerged as useful building blocks for well‐defined nanostructures with controlled size and dimensions. Short peptides in particular have received much attention due to their inherent biocompatibility, lower synthetic cost, and ease of tunability. In addition to the diverse self‐assembling properties of short peptides comprising coded amino acids and their emerging applications in nanotechnology, there is now growing interest in the properties of peptides composed of non‐canonical amino acids. Such non‐natural oligomers have been shown in recent years to form well‐defined secondary structures similar to natural proteins, with the ability to self‐assemble to generate a wide variety of nanostructures with excellent biostability. This review describes recent events in the development of supramolecular assemblies of peptides composed completely of non‐coded amino acids and their hybrid analogues. Special attention is paid to understanding the supramolecular assemblies at the atomic level and to considering their potential applications in nanotechnology. Non‐natural oligomers have a high propensity to form well‐defined secondary structures similar to natural proteins and have the ability self‐organize into a wide variety of three dimensional supramolecular architectures with excellent biocompatibility. This review describes recent developments in supramolecular assemblies of peptides composed of non‐natural amino acids and their applications in bionanotechnology.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.202100090