Distribution of Fluoride in Plasma, Brain, and Bones and Associated Oxidative Damage After Induced Chronic Fluorosis in Wistar Rats

The study was aimed to determine fluoride levels in plasma, brain, and bones of Wistar rats following chronic administration of fluoride at different dose levels and the consequent oxidative damage inflicted in these tissues. Brain histomorphology and bone radiographs were also evaluated to assess t...

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Bibliographic Details
Published in:Biological trace element research 2022-04, Vol.200 (4), p.1710-1721
Main Authors: Sharma, Priyanka, Verma, Pawan K., Sood, Shilpa, Singh, Rajiv, Gupta, Ajay, Rastogi, Ankur
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - metabolism
Animal tissues
Animals
Biochemistry
Biomedical and Life Sciences
Biotechnology
Body organs
Bone density
Bone marrow
Bone matrix
Bone remodeling
Bones
Brain
Brain - diagnostic imaging
Brain - metabolism
Brain damage
Catalase
Cerebellum
Cerebrum
Cortical bone
Drinking water
Fluorides
Fluorides - metabolism
Fluorides - toxicity
Fluorosis
Gliosis
Glutathione
Glutathione peroxidase
Glutathione reductase
Haemorrhage
Hemorrhage
Intoxication
Life Sciences
Lipid Peroxidation
Lipids
Mineralization
Necrosis
Nutrition
Oncology
Organs
Ossification
Oxidative Stress
Peroxidase
Peroxidation
Plasma
Rats
Rats, Wistar
Reductases
Rodents
Sodium Fluoride - toxicity
Superoxide dismutase
Superoxide Dismutase - metabolism
Tensile strength
Thiols
Tissue
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Summary:The study was aimed to determine fluoride levels in plasma, brain, and bones of Wistar rats following chronic administration of fluoride at different dose levels and the consequent oxidative damage inflicted in these tissues. Brain histomorphology and bone radiographs were also evaluated to assess the extent of damage in these organs. Eighteen rats were randomly divided into three groups with six animals in each group. Group I served as control and groups II and III received 50 and 100 ppm fluoride in tap water, respectively for 180 days. A dose-dependent rise in the levels of fluoride in plasma, brain, and bones was observed in rats. Significant (P 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-021-02782-3