Dietary nutrients and their control of the redox bioenergetic networks as therapeutics in redox dysfunctions sustained pathologies

Electrons exchange amongst the chemical species in an organism is a pivotal concomitant activity carried out by individual cells for basic cellular processes and continuously contribute towards the maintenance of bioenergetic networks plus physiological attributes like cell growth, phenotypic differ...

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Bibliographic Details
Published in:Pharmacological research 2021-08, Vol.170, p.105709-105709, Article 105709
Main Authors: Kuchi Bhotla, Haripriya, Meyyazhagan, Arun, Pappusamy, Manikantan, Park, Sungkwon, Arumugam, Vijaya Anand, Pushparaj, Karthika, Rengasamy, Kannan RR, Liu, Wenchao, Balasubramanian, Balamuralikrishnan
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - adverse effects
Diet
Energy Metabolism - drug effects
Humans
Inflammation Mediators - metabolism
Metabolic Diseases - drug therapy
Metabolic Diseases - metabolism
Metabolic Diseases - pathology
Micronutrients
Micronutrients - administration & dosage
Micronutrients - adverse effects
Mitochondria - drug effects
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrion
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Oxidation-Reduction
Oxidative Stress - drug effects
Pathological condition
Reactive Oxygen Species - metabolism
Reactive species
Reduction-oxidation
Thiol groups
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Summary:Electrons exchange amongst the chemical species in an organism is a pivotal concomitant activity carried out by individual cells for basic cellular processes and continuously contribute towards the maintenance of bioenergetic networks plus physiological attributes like cell growth, phenotypic differences and nutritional adaptations. Humans exchange matter and energy via complex connections of metabolic pathways (redox reactions) amongst cells being a thermodynamically open system. Usually, these reactions are the real lifeline and driving forces of health and disease in the living entity. Many shreds of evidence support the secondary role of reactive species in the cellular process of control apoptosis and proliferation. Disrupted redox mechanisms are seen in malaises, like degenerative and metabolic disorders, cancerous cells. This review targets the importance of redox reactions in the body's normal functioning and the effects of its alterations in cells to obtain a better understanding. Understanding the redox dynamics in a pathological state can provide an opportunity for cure or diagnosis at the earlier stage and serve as an essential biomarker to predict in advance to give personalized therapy. Understanding redox metabolism can also highlight the use of naturally available antioxidant in the form of diet. [Display omitted] •Redox is the lingua franca of the body and maintenance of cellular health.•Activities of mitochondria release the reactive species, peroxisomes, detached NO synthases.•Disruption in reactive species level leads to the tumorous and pathological environment.•Reactive species directly impact the major biomolecules like proteins, carbohydrates, nucleic acids, lipids.•Naturally available micronutrients can be obtained from the food and maintain reactive species levels by producing antioxidants.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2021.105709