NIR‐II Photoacoustic Reporter for Biopsy‐Free and Real‐Time Assessment of Wilson's Disease

Wilson's disease (WD) is a rare inherited disorder of copper metabolism with pathological copper hyperaccumulation in some vital organs. However, the clinical diagnosis technique of WD is complicated, aggressive, and time‐consuming. In this work, a novel ratiometric photoacoustic (PA) imaging n...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2021-07, Vol.17 (26), p.e2008061-n/a
Main Authors: Fu, Qinrui, Ye, Jiamin, Wang, Juejun, Liao, Naishun, Feng, Hongjuan, Su, Lichao, Ge, Xiaoguang, Yang, Huanghao, Song, Jibin
Format: Article
Language:English
Subjects:
Biopsy
biosensing
Copper
Diagnosis
In vivo methods and tests
Injury prevention
Liver
Medical imaging
Nanorods
Nanotechnology
NIR‐II
Organs
Palladium
photoacoustic imaging
ratiometric nanoprobe
Wilson's disease
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Summary:Wilson's disease (WD) is a rare inherited disorder of copper metabolism with pathological copper hyperaccumulation in some vital organs. However, the clinical diagnosis technique of WD is complicated, aggressive, and time‐consuming. In this work, a novel ratiometric photoacoustic (PA) imaging nanoprobe in the NIR‐II window is developed to achieve noninvasive, rapid, and accurate Cu2+ quantitative detection in vitro and in vivo. The nanoprobe consists of Cu2+‐responsive IR970 dye and a nonresponsive palladium‐coated gold nanorod (AuNR‐Pd), achieving a concentration‐dependent ratiometric PA970/PA1260 signal change. The urinary Cu2+ content is detectable within minutes down to a detection limit of 76 × 10−9 m. This report acquisition time is several orders of magnitude shorter than those of existing detection approaches requiring complex procedure. Moreover, utilizing the ratiometric PA nanoprobe, PA imaging enables biopsy‐free measurement of the liver Cu2+ content and visualization of the liver Cu2+ biodistribution of WD patient, which avoid the body injury during the clinical Cu2+ test using liver biopsy method. The NIR‐II ratiometric PA detection method is simple and noninvasive with super precision, celerity, and simplification, which holds great promise as an alternative to liver biopsy for clinical diagnosis of WD. Quantitative detection of urinary Cu2+ and in vivo visualization of Wilson's disease‐involved Cu2+ distribution in the liver with rapidity, sensitivity and noninvasion can be achieved via the second near‐infrared window ratiometric photoacoustic nanoprobe. The simple, time‐saving, visual and safe method can act as an alternative to the current clinical detection methods for the Wilson's disease diagnosis.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202008061