Serum Elemental Analysis of Type 2 Diabetes Patients Using SRXRF

A total of 158 serum samples of newly diagnosed type 2 diabetes patients and control subjects were analyzed using Synchrotron Radiation X-ray Fluorescence (SRXRF) technique. The microprobe XRF beam line-16 of Indus-2 synchrotron radiation facility at Raja Ramanna Centre for Advanced Technology (RRCA...

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Bibliographic Details
Published in:Biological trace element research 2022-04, Vol.200 (4), p.1485-1494
Main Authors: Rao, N. Srinivasa, Raju, G. J. Naga, Tiwari, M. K., Naidu, B. G., Sarita, P.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biotechnology
Calcium
Chromium
Cobalt
Copper
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Fluorescence
Homeostasis
Humans
India
Insulin
Iron
Lead
Life Sciences
Manganese
Nickel
Nutrition
Oncology
Oxidative stress
Radiation
Selenium
Serum
Synchrotron radiation
Synchrotrons
Trace Elements - analysis
Uptake
X-ray fluorescence
X-Rays
Zinc
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Summary:A total of 158 serum samples of newly diagnosed type 2 diabetes patients and control subjects were analyzed using Synchrotron Radiation X-ray Fluorescence (SRXRF) technique. The microprobe XRF beam line-16 of Indus-2 synchrotron radiation facility at Raja Ramanna Centre for Advanced Technology (RRCAT), Indore, India, was used to identify and quantify the elements K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb. A significant decrease in the mean concentrations of K, Ca, Ti, Cr, Mn, Ni, Zn, and As and an increase in the concentrations of V, Fe, Co, Cu, Se, and Pb were observed in the serum samples of the patient group when compared to the control group. It is hypothesized that the observed alterations in the elemental concentrations might have led to ineffective uptake of insulin and have interfered with glucose homeostasis by either directly or indirectly causing oxidative stress.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-021-02762-7