Age-Related Features of the Response of the Liver and Stem Cells during Modeling of Liver Cirrhosis

We studied the age-related characteristics of the response of stem cells and liver in male Wistar rats to administration of carbon tetrachloride (CCl 4 ) and ethanol. It was shown that modeling of liver cirrhosis caused inflammation, fibrosis, damage to sinusoidal capillaries, necrosis, and disturba...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2021-05, Vol.171 (1), p.127-133
Main Authors: Skurikhin, E. G., Zhukova, M. A., Pan, E. S., Ermakova, N. N., Pershina, O. V., Pakhomova, A. V., Putrova, O. D., Sandrikina, L. A., Krupin, V. A., Kogai, L. V., Rebrova, T. Yu, Afanas’ev, S. A., Dygai, A. M.
Format: Article
Language:English
Subjects:
Age
Analysis
Animals
Biomedical and Life Sciences
Biomedicine
Bone marrow
Capillaries
Carbon tetrachloride
Carbon Tetrachloride - toxicity
CCL4 protein
Cell Biology
Cirrhosis
Endothelial Cells
Ethanol
Fibrosis
Hematopoietic stem cells
Hepatocytes
Hepatocytes - pathology
Inflammation
Internal Medicine
Laboratory Medicine
Leukocyte migration
Liver - metabolism
Liver cirrhosis
Liver Cirrhosis - metabolism
Lymphocytes
Male
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Mesenchyme
Pathology
Rats
Rats, Wistar
Rodents
Sox9 protein
Stem cell transplantation
Stem cells
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Summary:We studied the age-related characteristics of the response of stem cells and liver in male Wistar rats to administration of carbon tetrachloride (CCl 4 ) and ethanol. It was shown that modeling of liver cirrhosis caused inflammation, fibrosis, damage to sinusoidal capillaries, necrosis, and disturbances in the functional activity of hepatocytes in young rats. These processes were accompanied by mobilization of profibrotic mesenchymal stem cells (MSC), proinflammatory hematopoietic stem cells (HSC) and lymphocytes (CD45 hi CD133 + ) from the bone marrow into the blood and migration to the liver. On the other hand, the number of hepatocyte precursors expressing Sox9 (cells of Hering’s canal), immature cholangiocytes, Ito cells, oval cells, and endothelial cells of the liver sinusoids) sharply increased in the liver. In young rats, mobilization and migration of MSC, HSC, and hepatocyte precursors against the background of liver cirrhosis were more intensive than in old animals. The higher resistance of old rats to exposure is associated with age-related changes in the niches as well as in mobilization and migration of cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05184-6