Candidate Allergens for Inclusion in the Spanish Standard Series Based on Data from the Spanish Contact Dermatitis Registry

Candidate Allergens for Inclusion in the Spanish Standard Series Based on Data from the Spanish Contact Dermatitis Registry

BACKGROUNDStandard patch test series must be updated using objective data on allergen sensitization. The Spanish standard series was last updated in 2016 and the European series in 2019, and the inclusion of several emerging allergens needs to be evaluated. MATERIAL AND METHODSWe conducted a prospec...

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Published in:Actas dermo-sifiliográficas (English ed.) 2021-10
Main Authors: Hernández-Fernández, Carlos Pelayo, Mercader-García, Pedro, Silvestre Salvador, Juan Francisco, Sánchez Pérez, Javier, Fernández Redondo, Virginia, Miquel Miquel, Francisco Javier, Ortiz de Frutos, Francisco Javier, Gatica Ortega, María Elena, Mora Fernández, Verónica, Giménez Arnau, Ana María, Zaragoza Ninet, Violeta, González Pérez, Ricardo, Sanz Sánchez, Tatiana, Pastor Nieto, María Antonia, Serra Baldrich, Esther, Córdoba Guijarro, Susana, Heras Mendaza, Felipe, Ruiz González, Inmaculada, Rodríguez Serna, Mercedes, Hervella Garcés, Marcos, Gallego Descalzo, Miguel Ángel, García Doval, Ignacio, Borrego Hernando, Leopoldo
Format: Article
Language:eng ; spa
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Summary:BACKGROUNDStandard patch test series must be updated using objective data on allergen sensitization. The Spanish standard series was last updated in 2016 and the European series in 2019, and the inclusion of several emerging allergens needs to be evaluated. MATERIAL AND METHODSWe conducted a prospective, observational, multicenter study of consecutive patients from the registry of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) who were patch tested in 2019 and 2020 with linalool hydroperoxide, limonene hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazolinone, octylisothiazolinone, textile dye mix (TDM), sodium metabisulfite, propolis, bronopol, Compositae mix II, diazolidinyl urea, imidazolidinyl urea, decyl glucoside, and lauryl glucoside. RESULTSWe analyzed data for 4654 patients tested with diazolidinyl urea, imidazolidinyl urea, and bronopol, and 1890 tested with the other allergens. The values for the MOAHLFA index components were 30% for male, 18% for occupational dermatitis, 15% for atopic dermatitis, 29% for hand, 6.5% for leg, 23% for face, and 68% for age > 40 years. Sensitization rates above 1% were observed for 7 allergens: linalool hydroperoxide, 2-hydroxyethyl-methacrylate, benzisothiazolinone, limonene hydroperoxide, TDM, sodium metabisulfite, and propolis. Three allergens had a current relevance rate of over 1%: linalool hydroperoxide, 2-hydroxyethyl-methacrylat, and limonene hydroperoxide. Benzisothiazolinone and TDM had a relevance rate of between 0.9% and 1%. CONCLUSIONSOur results indicate that 7 new allergens should be considered when extending the Spanish standard patch test series. The data from our series could be helpful for guiding the next extension of the European baseline series.
ISSN:1578-2190