White matter abnormalities associated with ADHD outcomes in adulthood

It remains unclear if previously reported structural abnormalities in children with ADHD are present in adulthood regardless of clinical outcome. In this study, we examined the extent to which focal-rather than diffuse-abnormalities in fiber collinearity of 18 major white matter tracts could disting...

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Bibliographic Details
Published in:Molecular psychiatry 2021-11, Vol.26 (11), p.6655-6665
Main Authors: Versace, A, Jones, N P, Joseph, H M, Lindstrom, R A, Wilson, T K, Lima Santos, J P, Gnagy, E M, Pelham, Jr, W E, Ladouceur, C D, Molina, B S G
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Adulthood
Adults
Age
Anisotropy
Attention Deficit Disorder with Hyperactivity
Attention deficit hyperactivity disorder
Brain
Brain - diagnostic imaging
Child
Child, Preschool
Children
Cingulum
Complications and side effects
Diffusion Tensor Imaging
Handedness
Health aspects
Humans
Nerve Net
Spatial memory
Substantia alba
White Matter - diagnostic imaging
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Summary:It remains unclear if previously reported structural abnormalities in children with ADHD are present in adulthood regardless of clinical outcome. In this study, we examined the extent to which focal-rather than diffuse-abnormalities in fiber collinearity of 18 major white matter tracts could distinguish 126 adults with rigorously diagnosed childhood ADHD (ADHD; mean age [SD] = 34.3 [3.6] years; F/M = 12/114) from 58 adults without ADHD histories (non-ADHD; mean age [SD] = 33.9 [4.1] years; F/M = 5/53) and if any of these abnormalities were greater for those with persisting ADHD symptomatology. To this end, a tract profile approach was used. After accounting for age, sex, handedness, and comorbidities, a MANCOVA revealed a main effect of group (ADHD 
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-021-01153-7