Design concepts for DNA-encoded library synthesis

[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2021-07, Vol.41, p.116189-116189, Article 116189
Main Authors: Zhang, Y., Clark, M.A.
Format: Article
Language:English
Subjects:
DNA-Encoded Library
Medicinal Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13
cites cdi_FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13
container_end_page 116189
container_issue
container_start_page 116189
container_title Bioorganic & medicinal chemistry
container_volume 41
creator Zhang, Y.
Clark, M.A.
description [Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven screening.
doi_str_mv 10.1016/j.bmc.2021.116189
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2532240917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0968089621001978</els_id><sourcerecordid>2532240917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EEuXxA9gysiT42o4fYqpaXlIFC8yWa9-AqzQpdorUf0-qMDPd5TtH93yE3ACtgIK821Trra8YZVABSNDmhMxASFFybuCUzKiRuqTayHNykfOGUsqEgRmBJeb42RW-7zzuhlw0fSqWr_MSO98HDEUb18mlQ5EP3fA1svmKnDWuzXj9dy_Jx-PD--K5XL09vSzmq9JzxYfS8MYYFSh66pwDwRXUKJxiYIITDrRSqtZKy4bXgjsWgkPtpNfGebV2wC_J7dS7S_33HvNgtzF7bFvXYb_PltWcMUENqBGFCfWpzzlhY3cpbsevLVB71GM3dtRjj3rspGfM3E8ZHDf8REw2-ziOxhAT-sGGPv6T_gUmg2vK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2532240917</pqid></control><display><type>article</type><title>Design concepts for DNA-encoded library synthesis</title><source>Elsevier</source><creator>Zhang, Y. ; Clark, M.A.</creator><creatorcontrib>Zhang, Y. ; Clark, M.A.</creatorcontrib><description>[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven screening.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2021.116189</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>DNA-Encoded Library ; Medicinal Chemistry</subject><ispartof>Bioorganic &amp; medicinal chemistry, 2021-07, Vol.41, p.116189-116189, Article 116189</ispartof><rights>2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13</citedby><cites>FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13</cites><orcidid>0000-0001-7263-9143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Clark, M.A.</creatorcontrib><title>Design concepts for DNA-encoded library synthesis</title><title>Bioorganic &amp; medicinal chemistry</title><description>[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven screening.</description><subject>DNA-Encoded Library</subject><subject>Medicinal Chemistry</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EEuXxA9gysiT42o4fYqpaXlIFC8yWa9-AqzQpdorUf0-qMDPd5TtH93yE3ACtgIK821Trra8YZVABSNDmhMxASFFybuCUzKiRuqTayHNykfOGUsqEgRmBJeb42RW-7zzuhlw0fSqWr_MSO98HDEUb18mlQ5EP3fA1svmKnDWuzXj9dy_Jx-PD--K5XL09vSzmq9JzxYfS8MYYFSh66pwDwRXUKJxiYIITDrRSqtZKy4bXgjsWgkPtpNfGebV2wC_J7dS7S_33HvNgtzF7bFvXYb_PltWcMUENqBGFCfWpzzlhY3cpbsevLVB71GM3dtRjj3rspGfM3E8ZHDf8REw2-ziOxhAT-sGGPv6T_gUmg2vK</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Zhang, Y.</creator><creator>Clark, M.A.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7263-9143</orcidid></search><sort><creationdate>20210701</creationdate><title>Design concepts for DNA-encoded library synthesis</title><author>Zhang, Y. ; Clark, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>DNA-Encoded Library</topic><topic>Medicinal Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Clark, M.A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic &amp; medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Y.</au><au>Clark, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design concepts for DNA-encoded library synthesis</atitle><jtitle>Bioorganic &amp; medicinal chemistry</jtitle><date>2021-07-01</date><risdate>2021</risdate><volume>41</volume><spage>116189</spage><epage>116189</epage><pages>116189-116189</pages><artnum>116189</artnum><issn>0968-0896</issn><eissn>1464-3391</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven screening.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.bmc.2021.116189</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7263-9143</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0968-0896
ispartof Bioorganic & medicinal chemistry, 2021-07, Vol.41, p.116189-116189, Article 116189
issn 0968-0896
1464-3391
language eng
recordid cdi_proquest_miscellaneous_2532240917
source Elsevier
subjects DNA-Encoded Library
Medicinal Chemistry
title Design concepts for DNA-encoded library synthesis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T02%3A20%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Design%20concepts%20for%20DNA-encoded%20library%20synthesis&rft.jtitle=Bioorganic%20&%20medicinal%20chemistry&rft.au=Zhang,%20Y.&rft.date=2021-07-01&rft.volume=41&rft.spage=116189&rft.epage=116189&rft.pages=116189-116189&rft.artnum=116189&rft.issn=0968-0896&rft.eissn=1464-3391&rft_id=info:doi/10.1016/j.bmc.2021.116189&rft_dat=%3Cproquest_cross%3E2532240917%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-93f997d0ec0aaa143715e4a7219da4a1877758786f3543a2ddae8a6c89ac7ba13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2532240917&rft_id=info:pmid/&rfr_iscdi=true