Design concepts for DNA-encoded library synthesis

[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2021-07, Vol.41, p.116189-116189, Article 116189
Main Authors: Zhang, Y., Clark, M.A.
Format: Article
Language:English
Subjects:
DNA-Encoded Library
Medicinal Chemistry
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Summary:[Display omitted] An approach of building block (BB) inclusivity and atom efficient library schemes deliver the quality and diversity of DNA-encoded libraries best suited for small molecule drug discovery. In this Perspective, we offer key learnings in DEL design from a decade’s worth of DEL-driven screening.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2021.116189