Effect of an intensified individual nutrition therapy on serum metabolites in critically ill patients – A targeted metabolomics analysis of the ONCA study

The effect of medical nutrition on serum metabolomics has been poorly explored. The aim of the study was to investigate the relation between energy supply and metabolic profiles in critically ill patients. Twenty mechanically ventilated patients on enteral nutrition (EN) or enteral/parenteral nutrit...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2021-06, Vol.43, p.267-275
Main Authors: Gonzalez-Granda, Anita, Seethaler, Benjamin, Haap, Michael, Riessen, Reimer, Bischoff, Stephan C.
Format: Article
Language:English
Subjects:
Critical illness
Indirect calorimetry
Medical nutrition
Nutrition therapy
Targeted metabolomics
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Summary:The effect of medical nutrition on serum metabolomics has been poorly explored. The aim of the study was to investigate the relation between energy supply and metabolic profiles in critically ill patients. Twenty mechanically ventilated patients on enteral nutrition (EN) or enteral/parenteral nutrition (EN/PN) were randomized into two groups. One group received an individual energy supply based on indirect calorimetry (IC group, n = 9), the other group received a standard energy supply based on a formula, the standard care group (SC group, n = 11). Targeted metabolomics was performed in early-, late- and post-acute metabolic phase. Individual versus standard care energy supply resulted in a metabolite class separation between the IC and the SC group (P 
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2021.04.002