Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine‐1 Trial)

Scope We have previously demonstrated the anti‐inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LP...

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Published in:Molecular nutrition & food research 2021-07, Vol.65 (14), p.e2100139-n/a
Main Authors: Cruz‐Chamorro, Ivan, Álvarez‐Sánchez, Nuria, Álvarez‐Ríos, Ana Isabel, Santos‐Sánchez, Guillermo, Pedroche, Justo, Millán, Francisco, Carrera Sánchez, Cecilio, Fernández‐Pachón, María Soledad, Millán‐Linares, María Carmen, Martínez‐López, Alicia, Lardone, Patricia Judith, Bejarano, Ignacio, Guerrero, Juan Miguel, Carrillo‐Vico, Antonio
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Arteriosclerosis
Atherosclerosis
Beverages
Biomarkers - blood
Blood
Cardiovascular diseases
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cytokines - metabolism
Density
Female
Functional foods & nutraceuticals
Health risks
Healthy Volunteers
High density lipoprotein
Humans
hydrolysate
Hydrolysates
Inflammation
Inflammatory response
Ingestion
Kidney
Leukocytes (mononuclear)
Leukocytes, Mononuclear - drug effects
Lipid metabolism
Lipids
Lipids - blood
Liver
Longitudinal Studies
Low density lipoprotein
lupine
Lupinus - chemistry
Male
Oxidants
Oxidative metabolism
Oxidative stress
Oxidative Stress - drug effects
Oxidizing agents
Peptides
Peripheral blood mononuclear cells
Protein Hydrolysates - pharmacology
Proteins
Risk analysis
Risk factors
Safety
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Summary:Scope We have previously demonstrated the anti‐inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. Methods and Results In this open‐label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants’ health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti‐/pro‐inflammatory response of PBMCs and improving the cellular anti‐oxidant capacity. LPHb also reduces the low‐density lipoprotein‐cholesterol (LDL‐C)/high‐density lipoprotein‐cholesterol (HDL‐C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL‐C/HDL‐C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well‐known cardiovascular risk factors. Conclusion This is the first study to show the pleiotropic actions of a lupine bioactive peptides‐based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism. The intake of a functional beverage based on Alcalase 2.4 L‐generates lupine protein hydrolysates for 28 days which increases the anti‐inflammatory microenvironment, as well as the cellular antioxidant capacity in healthy subjects. In addition, the intake of this beverage reduces the LDL‐C/HDL‐C atherogenic index.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.202100139